Mature enzymatic collagen cross-links, hydroxylysylpyridinoline and lysylpyridinoline, in the aging human vitreous

Investigative Ophthalmology & Visual Science
T L PonsioenLeonoor I Los

Abstract

The vitreous body of the human eye undergoes progressive morphologic changes with aging. Since the enzymatic collagen cross-links hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are known to be important for the integrity of the collagen matrix, the presence in the vitreous on aging was studied. Vitreous bodies (VBs; n = 143) from 119 donors (age 4-80 years; mean +/- SD, 54.3 +/- 17.0 years) were carefully dissected. After weighing and freeze-drying, all samples were analyzed by high performance liquid chromatography. Left and right eyes of 24 donors were compared and, for age-related phenomena, 119 single eyes were used. Within one donor, no significant differences were found between left and right eyes. On aging, VB wet weight (4.42 +/- 0.84 g) accumulates until 35 years and decreases thereafter. Collagen content (0.30 +/- 0.14 mg), HP per triple helix (TH; 0.55 +/- 0.18), and (HP plus LP)/TH (0.61 +/- 0.19) increase until 50 years followed by a decrease, whereas LP/TH (0.057 +/- 0.018) accumulates until 50 years and remains constant thereafter. The ratio between HP and LP (range, 0.42-31.0; median, 10.0) is constant over time. The accumulation of enzymatic collagen cross-links until 50 years is consistent with colla...Continue Reading

Citations

Jul 14, 2010·Progress in Retinal and Eye Research·Theodorus L PonsioenLeonoor I Los
Dec 5, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Adele L BoskeyRobert R Recker
Jul 29, 2016·Retina·Marielle van DeemterLeonoor I Los
Mar 11, 2020·Progress in Retinal and Eye Research·J Sebag
May 20, 2009·Experimental Eye Research·M van DeemterL I Los

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