Mature-onset obesity in interleukin-1 receptor I knockout mice

Diabetes
Maria C GarcíaJohn-Olov Jansson

Abstract

Interleukin-1 (IL-1) is a major mediator of inflammation that exerts its biological activities through the IL-1 type I receptor (IL-1RI). The body weights of IL-1RI(-/-) mice of both sexes started to deviate from those of wild-type mice at 5-6 months of age and were 20% higher at 9 months of age. Visceral and subcutaneous fat mass, measured by dual-energy X-ray absorptiometry and magnetic resonance imaging, was markedly (1.5- to 2.5-fold) increased. Lean body mass and crown-rump length were also slightly (11 and 5%, respectively) increased, as was serum IGF-I. Obese IL-1RI(-/-) mice were insulin resistant, as evidenced by hyperinsulinemia, decreased glucose tolerance, and insulin sensitivity. To elucidate the mechanisms for the development of obesity, young pre-obese IL-1RI(-/-) mice were investigated. They showed decreased suppression of body weight and food intake in response to systemic leptin treatment. The decreased leptin responsiveness was even more pronounced in older obese animals. Moreover, spontaneous locomotor activity and fat utilization, as measured by respiratory quotient, were decreased in pre-obese IL-1RI(-/-) mice. In conclusion, lack of IL-1RI-mediated biological activity causes mature-onset obesity. This obe...Continue Reading

References

Aug 1, 1992·The American Journal of Physiology·F ZurloE Ravussin
Nov 1, 1990·The American Journal of Physiology·F ZurloE Ravussin
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A del Rey, H Besedovsky
Aug 1, 1986·Endocrine Reviews·L A Frohman, J O Jansson
Jul 18, 1996·Nature·R S AhimaJ S Flier
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·E HirschD Hirsh
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A del ReyH O Besedovsky
Jul 1, 1997·The American Journal of Physiology·B AhrénP J Havel
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KanemakiT Okumura
Jul 1, 1998·International Reviews of Immunology·C A Dinarello
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·G N LuheshiN J Rothwell
Nov 1, 2000·Nature·M TschöpM L Heiman
Aug 10, 2001·Physiology & Behavior·R B HarrisD H Ryan
Jan 12, 2002·Nature Medicine·Ville WalleniusJohn-Olov Jansson
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Haiying TangDympna Gallagher
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Christoph A MeierJean-Michel Dayer
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Olof H HultgrenAndrej Tarkowski
Jun 11, 2002·Biochemical and Biophysical Research Communications·Kristina WalleniusJohn-Olov Jansson
Jun 11, 2002·Annual Review of Nutrition·Marc L Reitman
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Senri OguriYasuo Endo
Mar 21, 2003·The New England Journal of Medicine·I Sadaf FarooqiStephen O'Rahilly
Apr 11, 2003·Reviews of Physiology, Biochemistry and Pharmacology·D KamimuraT Hirano
Sep 17, 2003·The Journal of Experimental Medicine·Taizo MatsukiYoichiro Iwakura
Jan 6, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S E ShoelsonM Yuan
Jan 30, 2004·Recent Progress in Hormone Research·Kate L J Ellacott, Roger D Cone
Jan 30, 2004·Recent Progress in Hormone Research·I S Farooqi, S O'Rahilly
Feb 28, 2004·Endocrinology·Jenny FäldtJohn-Olov Jansson
Jun 1, 2004·Nature Medicine·Jeffrey M Friedman
Jun 12, 2004·American Journal of Physiology. Endocrinology and Metabolism·Gina B Di GregorioPhilip A Kern
Aug 11, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·I WernstedtJ-O Jansson
Aug 12, 2004·American Journal of Physiology. Endocrinology and Metabolism·Brent E WisseMichael W Schwartz

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Citations

Oct 3, 2008·Archives of Virology·Magdalena PasaricaNikhil V Dhurandhar
Mar 9, 2013·Frontiers of Medicine·Jianping Ye
Mar 18, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N AnderssonJ-O Jansson
Apr 13, 2007·The New England Journal of Medicine·Claus M LarsenMarc Y Donath
Feb 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Manuel Sanchez-AlavezTamas Bartfai
Jun 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Eric P ZorrillaBruno Conti
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·J A EhsesM Y Donath
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Barbara BecattiniGiovanni Solinas
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maya E KotasRuslan Medzhitov
Sep 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rozita ShiraziKarolina Patrycja Skibicka
Jul 25, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chidozie J AmuzieJames J Pestka
Oct 7, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chidozie J Amuzie, James J Pestka
Apr 8, 2010·American Journal of Physiology. Endocrinology and Metabolism·Shinsuke Oh-IMichael W Schwartz
Dec 28, 2012·American Journal of Physiology. Endocrinology and Metabolism·Jianping Ye, Owen P McGuinness
Feb 10, 2012·American Journal of Physiology. Endocrinology and Metabolism·Nathalie PamirRenée C LeBoeuf
Sep 21, 2013·Reviews in Endocrine & Metabolic Disorders·H L KammounM A Febbraio
Mar 13, 2012·Annual Review of Nutrition·Shengyi SunLing Qi
Sep 27, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Hadi KhodabandehlooReza Meshkani
Jan 1, 2013·Toxicology Letters·Chanemougasoundharam Arunachalam, Fiona M Doohan
Mar 30, 2010·Physiology & Behavior·Aaron J GrossbergDaniel L Marks
Dec 23, 2009·Molecular and Cellular Endocrinology·Sylvia P PoulosGary J Hausman
Oct 14, 2009·Frontiers in Neuroendocrinology·Joshua P ThalerBrent E Wisse
Dec 20, 2014·Neuroscience and Biobehavioral Reviews·Matthew W HaleLuba Sominsky
Apr 11, 2007·Journal of Neurochemistry·Emmanuel PinteauxGiamal N Luheshi
Nov 1, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G Solinas
Mar 16, 2012·Annals of the New York Academy of Sciences·Dongsheng Cai, Tiewen Liu
Oct 5, 2016·JCI Insight·Catherine HajmrlePatrick E MacDonald

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