Mature Testicular Teratoma with Positive Estrogen Receptor Beta Expression in a Transgendered Individual on Cross-Sex Hormonal Therapy: A Case Report

LGBT Health
Yoshitomo KoboriHiroshi Okada

Abstract

Estrogen exposure has been linked to a risk of testicular germ cell cancers, although predominantly in animal studies. In the human testis, estrogen receptor beta (ER-β) mediates the physiological action of estrogen. We describe a case of a 30-year-old transgender woman (male-to-female [MtF]) with gender dysphoria who developed a mature testicular teratoma with positive estrogen receptor beta expression while receiving cross-sex hormonal therapy with estradiol and progesterone. Although the presence of hormone receptors does not always imply that hormones have played a role in the development of the tumor, a contribution of exposure to exogenous estrogen in this case cannot be ruled out.

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Citations

Dec 25, 2015·LGBT Health·Carolyn S Wolf-Gould, Christopher H Wolf-Gould
Jan 17, 2019·LGBT Health·Elizabeth J KvachMarci Bowers
Sep 14, 2019·Therapeutic Advances in Endocrinology and Metabolism·Sean J IwamotoGuy T'Sjoen
Jul 16, 2020·Journal of the Endocrine Society·Ghada ElshimyRicardo Correa
Dec 29, 2020·Plastic and Reconstructive Surgery·Adam JacobyRachel Bluebond-Langner

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