PMID: 9428104Jan 15, 1998Paper

Maurício Rocha e Silva MD: snake venom, bradykinin and the rise of autopharmacology

Toxicon : Official Journal of the International Society on Toxinology
B J Hawgood

Abstract

Maurício Rocha e Silva is well known as the discoverer of bradykinin, the powerful hypotensive and smooth muscle stimulating polypeptide which was first detected in plasma following the addition of Bothrops jararaca venom. The discovery in São Paulo, Brazil, in 1948 was the outcome of studies on proteolytic enzymes that Rocha e Silva started in 1939 at a time when circulatory shock was considered to be mediated by histamine. This line of research was prompted by the publications of Feldberg and Kellaway which identified the release of histamine and a slow-reacting substance (SRC-C) from isolated lungs perfused with Naja venom. Rocha e Silva was interested in determining whether trypsin-like enzymes, as shown for phospholipase, had a role in the release of histamine in shock. Instead, he and his co-workers demonstrated that such an enzyme released a new autopharmacological principle, bradykinin, from a plasma globulin precursor. Studies by Ferreira and Rocha e Silva on ways of blocking plasma kinin-destroying activity led Ferreira to isolate bradykinin-potentiating peptides from B. jararaca venom. These peptides were later shown to block angiotensin-I converting enzyme and so have an effect on hypertension. The discovery of brad...Continue Reading

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Citations

May 7, 2005·Toxicon : Official Journal of the International Society on Toxinology·Márcia Regina SoaresMarcelo Ribeiro Vasconcelos Diniz
Jul 16, 2011·Nephron. Clinical Practice·Lívia Rodrigues SgrignolliEmmanuel A Burdmann
Aug 6, 2010·Toxicon : Official Journal of the International Society on Toxinology·Maria Elena de LimaJorge A Guimarães
May 25, 2005·Rapid Communications in Mass Spectrometry : RCM·Luciana Serrão WermelingerRussolina B Zingali
Oct 24, 2006·Biophysical Journal·Alejandra SáenzCristina Casals
Mar 2, 2005·Colloids and Surfaces. B, Biointerfaces·James J LuA Wilhelm Neumann
Dec 10, 2002·Analytical Biochemistry·Tianbao ChenChris Shaw
Feb 22, 2011·Toxicon : Official Journal of the International Society on Toxinology·Weiwei LeiYun Zhang
Apr 28, 2012·Toxicon : Official Journal of the International Society on Toxinology·Christopher J Bohlen, David Julius
Nov 6, 2010·Toxicon : Official Journal of the International Society on Toxinology·Yong ZhangQiumin Lu
May 29, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maria Christina W Avellar, Mauro M Teixeira
Oct 19, 2016·Molecular Pharmacology·André S Pupo, J Adolfo García-Sáinz
Apr 4, 2015·Cell Transplantation·Priscilla D NegraesHenning Ulrich
Jul 2, 2019·Current Topics in Medicinal Chemistry·Júlia G B PedreiraEliezer J Barreiro
Dec 4, 2019·Neuroscience and Biobehavioral Reviews·Benjamín RodríguezMirian A F Hayashi

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