MAVERICC, a Randomized, Biomarker-stratified, Phase II Study of mFOLFOX6-Bevacizumab versus FOLFIRI-Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Aparna R ParikhHeinz-Josef Lenz

Abstract

MAVERICC compared the efficacy and safety of modified leucovorin/5-fluorouracil/oxaliplatin plus bevacizumab (mFOLFOX6-BV) with leucovorin/5-fluorouracil/irinotecan plus bevacizumab (FOLFIRI-BV) in patients with previously untreated metastatic colorectal cancer (mCRC).Patients and Methods: MAVERICC was a global, randomized, open-label, phase II study. Primary objectives were to assess associations between (i) excision repair cross-complementing 1 (ERCC1) expression with progression-free survival (PFS), and (ii) plasma VEGF A (VEGF-A) with PFS in patients with previously untreated mCRC receiving mFOLFOX6-BV or FOLFIRI-BV. Before randomization, patients were stratified by tumoral ERCC1/β-actin mRNA expression level and region. Of 376 enrolled patients, 188 each received mFOLFOX6-BV and FOLFIRI-BV. PFS and overall survival (OS) were comparable between FOLFIRI-BV and mFOLFOX6-BV, with numerically higher PFS [HR = 0.79; 95% CI (confidence interval): 0.61-1.01; P = 0.06] and OS (HR = 0.76; 95% CI: 0.56-1.04; P = 0.09) observed for FOLFIRI-BV. In the high ERCC1 subgroup, PFS and OS were comparable between treatment groups (PFS, HR = 0.84; 95% CI: 0.56-1.26; P = 0.40; OS, HR = 0.80; 95% CI: 0.51-1.26; P = 0.33). Across treatment groups...Continue Reading

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Citations

Mar 12, 2019·International Journal of Cancer. Journal International Du Cancer·Ryuma TokunagaHeinz-Josef Lenz
Dec 10, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Syma IqbalHoward S Hochster
Mar 29, 2020·Signal Transduction and Targeted Therapy·Yuan-Hong XieJing-Yuan Fang
Jul 11, 2020·Cancer Metastasis Reviews·Gábor LakatosGyörgy Bodoky
Nov 12, 2020·Journal for Immunotherapy of Cancer·Hiroyuki AraiHeinz-Josef Lenz
Nov 16, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eric Van CutsemJosep Tabernero
Nov 15, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Karen BolhuisCornelis J A Punt
Dec 31, 2020·Cell Reports Medicine·Neda JabbariQiang Tian
Dec 10, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jim P AbrahamDavid B Spetzler
Apr 17, 2020·Signal Transduction and Targeted Therapy·Yuan-Hong XieJing-Yuan Fang
Mar 27, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroyuki AraiHeinz-Josef Lenz

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