Maxacalcitol (22-Oxacalcitriol (OCT)) Retards Progression of Left Ventricular Hypertrophy with Renal Dysfunction Through Inhibition of Calcineurin-NFAT Activity.

Cardiovascular Drugs and Therapy
Kazunori InoueYoshitaka Isaka

Abstract

Left ventricular hypertrophy (LVH) is a cardiovascular complication highly prevalent in patients with chronic kidney disease (CKD). Previous studies analyzing 1α-hydroxylase or vitamin D receptor (Vdr) knockout mice revealed active vitamin D as a promising agent inhibiting LVH progression. Paricalcitol, an active vitamin D analog, failed to suppress the progression of LV mass index (LVMI) in pre-dialysis patients with CKD. As target genes of activated VDR differ depending on its agonists, we examined the effects of maxacalcitol (22-oxacalcitriol: OCT), a less calcemic active vitamin D analog, on LVH in hemodialysis patients and animal LVH models with renal insufficiency. In retrospective cohort study, patients treated with OCT who underwent hemodialysis were enrolled. Using cardiac echocardiography, LV mass was evaluated by the area-length method. In animal study, angiotensin II (Ang II)-infused Wister rats with heminephrectomy or Ang II-stimulated neonatal rat ventricular myocytes (NRVM) were treated with OCT. OCT significantly inhibited the progression of LVMI in hemodialysis patients. In Ang II-infused heminephrectomized rats, OCT suppressed the progression of LVH in a blood pressure-independent manner. OCT also suppressed t...Continue Reading

References

Dec 15, 1995·Cell·D J Mangelsdorf, R M Evans
Oct 28, 1998·Physiological Reviews·G JonesH F DeLuca
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C W ParkB K Bang
Jul 13, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A LevinO Djurdjev
Feb 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Erik BushEric N Olson
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Wei XiangYan Chun Li
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ernesto PaolettiGiuseppe Cannella
Nov 4, 2006·The EMBO Journal·Naoya OnoharaHitoshi Kurose
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Natalya BodyakPeter M Kang
Mar 19, 2008·Cardiovascular Research·Yasuhiro YamamotoJunichi Azuma
Mar 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Isao MatsuiYoshitaka Isaka
Sep 22, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Toshiaki NakanoKatsuo Sueishi
Dec 16, 2011·The Biochemical Journal·James C FleetYan Li
Feb 18, 2012·JAMA : the Journal of the American Medical Association·Ravi ThadhaniScott D Solomon
Mar 1, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Chikako NakanoHiromi Rakugi
Aug 29, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kazunori InoueHiromi Rakugi
Sep 1, 2012·Journal of the American Society of Nephrology : JASN·Meyeon ParkUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Group
Jan 25, 2013·American Journal of Physiology. Renal Physiology·Isao MatsuiYoshitaka Isaka
Jun 26, 2013·American Journal of Nephrology·Naim IssaHassan N Ibrahim
Aug 16, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Kathrin UnterstellerGunnar H Heine
May 13, 2018·Kidney International·Isao MatsuiYoshitaka Isaka
Jun 22, 2019·Journal of Cachexia, Sarcopenia and Muscle·Christian M GirgisJenny E Gunton

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