Maxicircle (mitochondrial) genome sequence (partial) of Leishmania major: gene content, arrangement and composition compared with Leishmania tarentolae

Gene
Lalani YatawaraTakeshi Agatsuma

Abstract

We report 8420 bp of DNA sequence data from the maxicircle (mitochondrial) genome of Leishmania major (MHOM/SU/73/5ASKH), a much larger portion of this genome than has been reported previously from any Leishmania species infecting humans. This region contains 10 partial and complete genes: 5 protein-encoding genes (COII, COIII, ND1, ND7 and Cyt b); two ribosomal RNA subunits (12S and 9S) and three unidentified open reading frames (MURF1, MURF4 (ATPase6) and MURF5), as in the lizard-infecting species L. tarentolae. The genes from L. major exhibit 85-87% identity with those of L. tarentolae at the nucleotide level and 71-94% identity at the amino acid level. Most differences between sequences from the two species are transversions. The gene order and arrangement within the maxicircle of L. major are similar to those in L. tarentolae, but base composition and codon usage differ between the species. Codons assigned for initiation for protein-coding genes available for comparison are similar in five genes in the two species. Pre-editing was identified in some of the protein-coding genes. Short intergenic non-coding regions are also present in L. major as they are in L. tarentolae. Intergenic regions between 9S rRNA and MURF5, MURF1 ...Continue Reading

References

Jan 1, 1992·International Review of Cytology·D R Wolstenholme
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E FeaginK Stuart
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·V F de la CruzL Simpson
Oct 1, 1984·Molecular and Biochemical Parasitology·B J JohnsonJ E Donelson
Mar 24, 1994·Nature·D A MaslovL Simpson
Feb 1, 1996·Molecular and Biochemical Parasitology·D E OchsL V Kirchhoff
Mar 25, 2000·International Journal for Parasitology·J E Feagin
Mar 31, 2000·Molecular Biology and Evolution·N J Tourasse, W H Li
Jul 26, 2002·Molecular Microbiology·Kenneth Stuart, Aswini K Panigrahi
Jul 1, 2004·Comparative Immunology, Microbiology and Infectious Diseases·P Desjeux
Sep 11, 2004·Current Molecular Medicine·Joseph Shlomai
Jun 22, 2005·Trends in Parasitology·Beiyu LiuPaul T Englund
Jul 16, 2005·Science·Alasdair C IvensPeter J Myler
Jan 31, 2006·Molecular and Biochemical Parasitology·Pavel N FlegontovAlexander A Kolesnikov
Jun 19, 2007·Nature Genetics·Christopher S PeacockMatthew Berriman
Apr 2, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Muntaser E IbrahimChristina Wasunna

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Citations

Dec 7, 2010·Parasitology Research·César RamírezJose M Requena
Feb 26, 2016·Molecular and Biochemical Parasitology·Alena ZíkováJulius Lukeš
Jan 21, 2014·Biochimie·Jonathan L HuotLaurence Maréchal-Drouard
May 8, 2010·Zoological Research·Hai-Feng Tian, Jian-Fan Wen
May 23, 2012·PLoS Pathogens·Roderick A M WilliamsGraham H Coombs
Jul 10, 2018·Parasitology Research·Brianna Norris-MullinsMiguel A Morales
Feb 14, 2020·Acta Parasitologica·Anjalie Amarasinghe, Susiji Wickramasinghe

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