Maxillary sinus floor augmentation with injectable calcium phosphate cements: a pre-clinical study in sheep

Clinical Oral Implants Research
Jan Willem M HoekstraJohn A Jansen

Abstract

The aim of this pre-clinical study was to evaluate the biological performance of two injectable calcium phosphate cement (CPC) composite materials containing poly(D,L-lactic-co-glycolic)acid (PLGA) microspheres with different properties in a maxillary sinus floor elevation model in sheep. PLGA microspheres were made of either low molecular weight (~17 kDa) acid-terminated PLGA (PLGA(L-AT) ) or high molecular weight (~44 kDa) end-capped PLGA (PLGA(H-EC) ) and incorporated in CPC. Eight female Swifter sheep underwent a bilateral maxillary sinus floor elevation procedure via an extra-oral approach. All animals received both materials, alternately injected in the left and right sinus (split-mouth model) and a time point of 12 weeks was used. Analysis of biological performance was based on histology, histomorphometry, and evaluation of sequential fluorochrome labeling. Both types of CPC-PLGA composites showed biocompatibility and direct bone-cement contact. CPC-PLGA(L-AT) showed a significantly higher degradation distance compared to CPC-PLGA(H-EC) (1949 ± 1295 μm vs. 459 ± 267 μm; P = 0.0107). Further, CPC-PLGA(L-AT) showed significantly more bone in the region of interest (26.4 ± 10.5% vs. 8.6 ± 3.9% for PLGA(H-EC) ; P = 0.0009) a...Continue Reading

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Citations

Mar 21, 2013·Acta Biomaterialia·Jan Willem M HoekstraJeroen J J P van den Beucken
Dec 25, 2012·Tissue Engineering. Part C, Methods·Manuela VenturaX Frank Walboomers
Apr 8, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Manuela VenturaX Frank Walboomers
Jun 7, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ninette TödtmannUwe Eckelt
Jan 23, 2018·Bone Research·Hockin Hk XuMark A Reynolds
Dec 10, 2016·Biomedical Materials·Eline-Claire GrosfeldJeroen J J P van den Beucken
Nov 22, 2017·NMR in Biomedicine·Weiqiang DouArend Heerschap

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