Maxillary sinus floor elevation using a tissue-engineered bone complex with OsteoBone and bMSCs in rabbits

Clinical Oral Implants Research
X-Juan SunL Lee Chou

Abstract

To evaluate the effects of maxillary sinus floor elevation by a tissue-engineered bone complex with OsteoBone(trade mark) and bone marrow stromal cells (bMSCs) in rabbits. Autologous bMSCs from adult New Zealand rabbits were cultured and combined with OsteoBone(trade mark) at a concentration of 20 x 10(6) cells/ml in vitro. Twenty-four animals were used and randomly allocated into groups. For each time point, 16 maxillary sinus floor elevation surgeries were made bilaterally in eight animals and randomly repaired by bMSCs/material (i.e. OsteoBone), material, autogenous bone and blood clot (n=4 per group). A polychrome sequential fluorescent labeling was also performed post-operatively. The animals were sacrificed 2, 4 and 8 weeks after the procedure and evaluated histologically as well as histomorphometrically. New bone area significantly decreased from weeks 2 to 8 in the blood clot group, while bone area in the autologous bone reduced from weeks 4 to 8. In both groups, a significant amount of fatty tissue appeared at week 8. Accordingly, augmented height in both groups was also significantly decreased from weeks 2 to 8. The bone area in the material-alone group as well as in the bMSCs/material group, on the other hand, increa...Continue Reading

References

Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A I Caplan
Jul 1, 1990·The Journal of Bone and Joint Surgery. British Volume·O BöstmanP Rokkanen
Mar 1, 1989·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J N Kent, M S Block
Jan 1, 1985·Acta Oto-laryngologica·J Kumlien, H Schiratzki
Jun 1, 1995·The Laryngoscope·K E ScharfP J Gannon
Apr 1, 1994·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S MintzI Horowitz
Nov 1, 1993·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·G M RaghoebarR P Van Oort
May 14, 1993·Science·R Langer, J P Vacanti
Nov 22, 1997·Journal of Biomedical Materials Research·J S SunF H Lin
Nov 26, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M S Block, J N Kent
Nov 26, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S L Wheeler
Apr 2, 1999·Science·M F PittengerD R Marshak
Apr 10, 1999·Clinical Oral Implants Research·G C LeghissaA R Botticelli
Aug 12, 1999·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·K WatanabeM Ueda
Sep 3, 1999·The Orthopedic Clinics of North America·C N Cornell
Jul 6, 2000·The Orthopedic Clinics of North America·J E FlemingG F Muschler
Apr 4, 2001·Artificial Organs·M UedaH Nakai
Jun 21, 2001·ANZ Journal of Surgery·W R MooreG I Bain
Mar 1, 2002·Journal of Biomedical Materials Research·J WiltfangP Kessler
Mar 14, 2002·Biochemical and Biophysical Research Communications·Felicity R A J Rose, Richard O C Oreffo
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carl G SimonFrancis W Wang
Jul 13, 2002·Journal of Biomedical Materials Research·François CornetJoseph Jeanfils
Aug 15, 2002·Clinical Oral Implants Research·Sumito AsaiKiyoshi Ooya
Jan 30, 2003·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Rainer SchmelzeisenMichael Sittinger
Sep 13, 2003·Clinical Oral Implants Research·Hui XuKiyoshi Ooya
May 6, 2004·The Journal of Surgical Research·Sophia Chia-Ning ChangSamir Mardinis
Jun 1, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Ronald Schimming, Rainer Schmelzeisen
Oct 7, 2004·Macromolecular Bioscience·António J SalgadoRui L Reis
Nov 17, 2004·Molecular and Cellular Biochemistry·F CornetJ Jeanfils
Jan 12, 2005·Clinical Oral Implants Research·Christine KnabeHala Zreiqat
Nov 22, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Philip J BoyneR Gilbert Triplett
Jan 17, 2007·Clinical Oral Implants Research·Christoph ZizelmannNils Claudius Gellrich

❮ Previous
Next ❯

Citations

Nov 19, 2009·Annals of Biomedical Engineering·Lei WangChangsheng Liu
Feb 25, 2011·Annals of Biomedical Engineering·Kaige LüFuqiang Zhang
Feb 9, 2012·Journal of Materials Science. Materials in Medicine·Ling XuFuqiang Zhang
Aug 23, 2012·Tissue Engineering. Part B, Reviews·Elisabet Farré-GuaschJenneke Klein-Nulend
Mar 11, 2010·The Journal of Craniofacial Surgery·Jun-Beom Park
Feb 8, 2011·Journal of Biomaterials Science. Polymer Edition·Kaige LüFuqiang Zhang
Apr 27, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Stefan Stübinger, Michel Dard
Mar 1, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Bo-Han YuZuo-Lin Wang
Mar 4, 2011·Biomaterials·Shaoyi WangZhiyuan Zhang
Jul 20, 2010·Clinical Oral Implants Research·Alessandro ScalaNiklaus Peter Lang
Aug 6, 2011·Clinical Implant Dentistry and Related Research·France LambertEric Rompen
Nov 4, 2010·Clinical Oral Implants Research·Kohei MarukawaEtsuhide Yamamoto
Oct 18, 2013·Clinical Implant Dentistry and Related Research·Shaoyi WangZhiyuan Zhang
Dec 18, 2014·Journal of Medical Case Reports·Nicolae ChipailaAnnalisa Monaco
May 4, 2017·Journal of Periodontal & Implant Science·Myung-Jae JooUi-Won Jung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.