Maxillomandibular Volume Influences the Relationship between Weight Loss and Improvement in Obstructive Sleep Apnea

Sleep
Kate SutherlandPeter A Cistulli

Abstract

Obesity is the major risk factor for OSA; however, weight loss reduces OSA to a variable extent. We aimed to assess whether size of the maxillomandibular skeletal enclosure influences the relationship between weight loss and OSA reduction. Obese males (≥ 30 kg/m2) with moderate-severe OSA (AHI > 15/h) participating in a 6-mo open-label weight loss program had craniofacial computed tomography (CT) scans before and after weight loss. CT scans were analysed using three-dimensional cephalometry. Maxillomandibular volume was calculated from skeletal landmarks on the mandible (condyle, gonion, menton) and maxilla (anterior nasal spine). Multiple regression analysis was used to test for moderating effects of maxillomandibular volume on relationship between changes in weight and apnea-hypopnea index (AHI). Fifty-two men (age 44.3 ± 8.8 y, AHI 42.9 ± 21.3 events/h, body mass index [BMI] 34.0 ± 2.7 kg/m2) had 7.4 ± 4.1% weight loss and 34.1 ± 32.4% AHI reduction at 6 months. BMI reduction modestly predicted AHI change (r2 = 0.17, P = 0.002). The interaction term of maxillomandibular volume and BMI change was a predictor of OSA improvement (P = 0.03), indicating maxillomandibular volume moderates this relationship. Subgroup analyses of pa...Continue Reading

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Citations

May 10, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Diane C LimAllan I Pack
Sep 1, 2017·Current Opinion in Pulmonary Medicine·Walter T McNicholas
Mar 31, 2019·Sleep & Breathing = Schlaf & Atmung·Kate SutherlandPeter A Cistulli
Dec 14, 2018·Multidisciplinary Respiratory Medicine·Kate SutherlandPeter A Cistulli
Apr 15, 2020·The Journal of Laryngology and Otology·F GaoD M Han
Feb 14, 2018·Expert Review of Respiratory Medicine·Kate SutherlandPeter A Cistulli

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