Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes

The Journal of Physiology
Eva PolákováEric A Sobie

Abstract

Refractoriness of calcium release in heart cells is altered in several disease states, but the physiological mechanisms that regulate this process are incompletely understood. We examined refractoriness of calcium release in mouse ventricular myocytes and investigated how activation of different intracellular signalling pathways influenced this process. We found that refractoriness of calcium release is abbreviated by stimulation of the 'fight-or-flight' response, and that simultaneous activation of multiple intracellular signalling pathways contributes to this response. Data obtained under several conditions at the subcellular, microscopic level were consistent with results obtained at the cellular level. The results provide insight into regulation of cardiac calcium release and how alterations to this process may increase arrhythmia risk under different conditions. Time-dependent refractoriness of calcium (Ca(2+)) release in cardiac myocytes is an important factor in determining whether pro-arrhythmic release patterns develop. At the subcellular level of the Ca(2+) spark, recent studies have suggested that recovery of spark amplitude is controlled by local sarcoplasmic reticulum (SR) refilling whereas refractoriness of spark ...Continue Reading

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Citations

Feb 6, 2017·Circulation Research·Pouya Tahsili-Fahadan, Romergryko G Geocadin
Aug 12, 2017·The Journal of General Physiology·Eric A SobieW J Lederer
Dec 14, 2018·The Journal of General Physiology·Duilio M PotenzaErnst Niggli
Mar 17, 2015·The Journal of Physiology·Donald M Bers, Ye Chen-Izu
Nov 1, 2017·Physiological Reports·Gregory P BartonGary Diffee
Sep 29, 2020·The Journal of General Physiology·Alejandra Cely-OrtizAlicia Mattiazzi
Aug 12, 2017·The Journal of General Physiology·Sándor GyörkePrzemysław B Radwański
Jun 15, 2018·The Journal of General Physiology·DeAnalisa C JonesEric A Sobie
Mar 16, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Alexey V ZaitsevMark Warren
Apr 10, 2016·The Journal of Physiology·Beth A HabeckerCrystal M Ripplinger

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