Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Afton L ThompsonHerman F Staats

Abstract

IL-1 has been shown to have strong mucosal adjuvant activities, but little is known about its mechanism of action. We vaccinated IL-1R1 bone marrow (BM) chimeric mice to determine whether IL-1R1 expression on stromal cells or hematopoietic cells was sufficient for the maximal adjuvant activity of nasally delivered IL-1α as determined by the acute induction of cytokine responses and induction of Bacillus anthracis lethal factor (LF)-specific adaptive immunity. Cytokine and chemokine responses induced by vaccination with IL-1α were predominantly derived from the stromal cell compartment and included G-CSF, IL-6, IL-13, MCP-1, and keratinocyte chemoattractant. Nasal vaccination of Il1r1(-/-) (knock-out [KO]) mice given wild-type (WT) BM (WT→KO) and WT→WT mice with LF + IL-1α induced maximal adaptive immune responses, whereas vaccination of WT mice given Il1r1(-/-) BM (KO→WT) resulted in significantly decreased production of LF-specific serum IgG, IgG subclasses, lethal toxin-neutralizing Abs, and mucosal IgA compared with WT→KO and WT→WT mice (p < 0.05). IL-1α adjuvant activity was not dependent on mast cells. However, the ability of IL-1α to induce serum LF-specific IgG2c and lethal toxin-neutralizing Abs was significantly impair...Continue Reading

References

Dec 1, 1995·Journal of Immunological Methods·M U Ferreira, A M Katzin
May 30, 1998·Clinical and Diagnostic Laboratory Immunology·C Mensi, F Pregliasco
Aug 6, 1998·European Journal of Immunology·A R SatoskarM Labow
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T YamamotoT Krieg
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F W van GinkelJ R McGhee
Jul 27, 2001·International Immunology·A K Wesa, A Galy
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D T GravesS Amar
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H F StaatsB F Haynes
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valerianna K Amorosa, Stuart N Isaacs
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristiana Kandere-GrzybowskaTheoharis C Theoharides
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jack B CowlandNiels Borregaard
Feb 27, 2004·The New England Journal of Medicine·Robert B Couch
Feb 27, 2004·The New England Journal of Medicine·Margot MutschRobert Steffen
Nov 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ayuko Sato, Akiko Iwasaki
Feb 1, 2005·Annals of the New York Academy of Sciences·Monica RimoldiMaria Rescigno
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sumana Chakravarty, Miles Herkenham
Oct 1, 2005·Lab Animal·William T GoldeLuis L Rodriguez
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolas NoulinIsabelle Couillin
May 27, 2006·The Lancet Infectious Diseases·David R HillDavid G Lalloo
Jun 27, 2006·AIDS Research and Human Retroviruses·Sushila K NordoneHerman F Staats
Nov 23, 2006·The Journal of Experimental Medicine·Milena BogunovicMiriam Merad
Sep 6, 2007·Indian Journal of Pediatrics·Abhiruchi GalhotraH M Swami
Feb 21, 2008·Journal of General Internal Medicine·Kelly K CurtisDonald W Northfelt
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja SeubertAndreas Wack
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catherine J SandersAndrew T Gewirtz
Nov 13, 2008·Infection and Immunity·Masja LeendertseTom van der Poll
Jan 6, 2009·Immunological Reviews·Olivier JoffreCaetano Reis e Sousa

❮ Previous
Next ❯

Citations

Mar 6, 2013·The Journal of Experimental Medicine·Shlomo Z Ben-SassonWilliam E Paul
Jul 5, 2013·Environmental Health Perspectives·Jessica L BoltonStaci D Bilbo
Feb 9, 2017·Clinical and Experimental Vaccine Research·Sae-Hae Kim, Yong-Suk Jang
Dec 17, 2014·Protein & Cell·Xiaoguang Wang, Delong Meng
Apr 19, 2013·Clinical and Experimental Vaccine Research·Joon Haeng RheeSoo Young Kim
Jul 26, 2012·Nature Reviews. Immunology·Nils Lycke
Jul 1, 2016·Applied Microbiology and Biotechnology·Christoph BuerthJoachim F Ernst
Mar 2, 2021·International Journal of Pharmaceutics·Kurt D RistrophRobert K Prud'homme
Sep 28, 2021·Frontiers in Immunology·Brandi T Johnson-WeaverHerman F Staats

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.