Maximal and submaximal endurance performance in adults with severe haemophilia

Haemophilia : the Official Journal of the World Federation of Hemophilia
M Herbsleb, T Hilberg

Abstract

Maximal exercise testing, including the determination of maximal performance and maximal oxygen uptake (VO(2max)), is considered the gold standard for assessing maximal endurance performance. The effectiveness of such testing is often reduced in haemophilic adults owing to musculoskeletal impairments or pain rather than because of cardiac exertion. The measurement of submaximal performance parameters overcomes many limitations of maximal exercise testing but a testing standard is still lacking. The aim of this study was to investigate maximal and particularly submaximal endurance performance of adult patients with severe haemophilia A and B. Eleven patients and 11 matched healthy controls were tested by spiroergometry with a specific treadmill test and the power was calculated in Watts. The haemophilic group achieved lower absolute (210 +/- 63 W) and weight-related (2.94 +/- 0.98 W kg(-1)) maximal endurance performance compared with the control group (287 +/- 50 W resp. 3.82 +/- 0.53 W kg(-1); P </= 0.05). The patients also showed a lower submaximal endurance performance at the individual anaerobic threshold (IAT = 147 +/- 56 W) and fixed lactate values (2 mmol = 98 +/- 60 W; 4 mmol = 158 +/- 56 W) compared with the healthy con...Continue Reading

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Citations

Mar 29, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·C NegrierL Heijnen
Jul 15, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·D CzepaT Hilberg
Jul 6, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·C R BroderickN van Doorn
Oct 9, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·D CzepaT Hilberg
Feb 18, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·E KurzT Hilberg
May 9, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·S Von MackensenW Zeller
Oct 7, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L VallejoF Querol
Apr 26, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·K FischerC M Kessler
Nov 3, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·E SherlockC Blake
Oct 23, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·S von MackensenT Hilberg
Nov 26, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·A McCarthyP Chowdary
Apr 12, 2014·Clinical Physiology and Functional Imaging·Luis Gustavo Normanton BeltrameDaniel Alexandre Boullosa
Jul 12, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·B RunkelT Hilberg
Oct 12, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·B RunkelT Hilberg
Jul 12, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·S KrügerT Hilberg
Mar 31, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Koeberlein-NeuT Hilberg
Sep 7, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J WildingC Hermans
Sep 20, 2019·Wiener klinische Wochenschrift·Barbara WagnerRichard Crevenna
Feb 25, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Barbara WagnerRichard Crevenna

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