PMID: 8601566Jan 1, 1996Paper

Maximal androgen blockade in combination with methotrexate for treatment of metastatic prostate cancer

Journal of Cancer Research and Clinical Oncology
P SagasterH Ludwig

Abstract

Recently attention has been focused on the optimal timing of chemotherapy within the treatment regimen for patients with metastatic prostate cancer, i.e., hormonal manipulation, preferably maximal androgen blockage (MAB) consisting of chemical/surgical castration followed by treatment with antiandrogens. We have conducted a randomized prospective clinical trial, investigating the efficacy and toxicity of MAB (orchiectomy followed by flutamide therapy) alone as compared to MAB combined with methotrexate (MTX, 50 mg/m2/week) in 53 patients with newly diagnosed stage IV(M1) prostatic cancer (UICC TNM Classification 1987). The observed remission rates (complete + partial) of 42.3% in the MAB + MTX arm and 29.6% in the MAB arm did not differ significantly. The response rates (complete + partial + stable disease) of 73.1% and 66.7% for MAB + MTX and MAB respectively, also showed no significant difference. Neither progression-free survival (median 18/5 and 23.8 months for MAB + MTX and MAB, respectively) nor overall survival (median: 37.4 and 36.1) months in the MAB + MTX and MAB arm, respectively) could be improved by the addition of MTX to MAB Only the extent of metastatic pain reported by the patients was consistently less under MA...Continue Reading

References

Oct 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C K OsborneR A Chapman
Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
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Citations

Dec 4, 1998·Urology·R Kirby
Mar 11, 2003·Prostate Cancer and Prostatic Diseases·D M PrestonD G McLeod
Dec 3, 2016·European Journal of Clinical Nutrition·J V Zhao, C M Schooling

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