Maximal expiratory pressure is associated with reinstitution of mechanical ventilation after successful unassisted breathing trials in tracheostomized patients with prolonged mechanical ventilation

PloS One
Shwu-Jen LinHuey-Dong Wu

Abstract

Reinstitution of mechanical ventilation (MV) for tracheostomized patients after successful weaning may occur as the care setting changes from critical care to general care. We aimed to investigate the occurrence, consequence and associated factors of MV reinstitution. We analyzed the clinical data and physiological measurements of tracheostomized patients with prolonged MV discharged from the weaning unit to general wards after successful weaning to compare between those with and without in-hospital MV reinstitution within 60 days. Of 454 patients successfully weaned, 116 (25.6%) reinstituted MV at general wards within 60 days; at hospital discharge, 42 (36.2%) of them were eventually liberated from MV, 51 (44.0%) remained MV dependent, and 33 (28.4%) died. Of the 338 patients without reinstitution within 60 days, only 3 (0.9%) were later reinstituted with MV before discharge (on day 67, 89 and 136 at general wards, respectively), and 322 (95.2%) were successfully weaned again at discharge, while 13 (3.8%) died. Patients with MV reinstitution had a significantly lower level of maximal expiratory pressure (PEmax) before unassisted breathing trial compared to those without reinstitution. Multivariable Cox regression analysis show...Continue Reading

References

May 23, 1991·The New England Journal of Medicine·K L Yang, M J Tobin
Jun 9, 2005·Critical Care Medicine·Joseph F DastaCatherine Tak Piech
Dec 16, 2005·Chest·Neil R MacIntyreUNKNOWN National Association for Medical Direction of Respiratory Care
Feb 3, 2006·The European Respiratory Journal·M VitaccaS Nava
Apr 11, 2009·Respiratory Medicine·Yao-Kuang WuYing-Huang Tsai
Jun 25, 2009·Critical Care : the Official Journal of the Critical Care Forum·Annalisa CarlucciStefano Nava
May 8, 2010·American Journal of Respiratory and Critical Care Medicine·Judith E NelsonShannon S Carson
Jun 1, 2010·Archives of Physical Medicine and Rehabilitation·Elliot J RothMichael Berkowitz
Feb 1, 2011·Respiratory Care·Alexandre TonnelierErwan L'Her
Jul 25, 2013·The Cochrane Database of Systematic Reviews·David J Berlowitz, Jeanette Tamplin
Oct 19, 2013·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Isabela M B Sclauser PessoaW Darlene Reid
Jan 11, 2014·Journal of the American Geriatrics Society·J Dermot FrengleyRobert J Kaner
Dec 8, 2017·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Chung-Shu LeeHsiung-Ying Huang
Jul 17, 2018·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Bernie BissettFrank Van Haren

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.