PMID: 9419218Jan 31, 1998Paper

Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand

The Journal of Experimental Medicine
I Suzuki, Pamela J Fink

Abstract

Fas ligand (FasL/CD95L) is best known for its role in delivering apoptotic signals through its receptor, Fas (APO-1/CD95). In this study, we present evidence that FasL has a second role as a signaling receptor. Alloantigen-specific proliferation by multiple FasL- murine CTL lines is depressed compared to that of FasL+ CTL lines. FasL- CTLs kill efficiently on a per recovered cell basis and can achieve wild-type levels of proliferation upon stimulation by optimal doses of anti-CD3, suggesting the lack of a costimulatory signal during antigen stimulation. To test this hypothesis directly, soluble FasIgG, a fusion protein of murine Fas and human IgG1, was added to FasL+ CTLs to demonstrate that blocking cell surface Fas-FasL interactions mimics the depression observed for FasL- CTLs. In addition, plate-bound FasIgG in conjunction with suboptimal anti-CD3 stimulation augments proliferative signals in FasL+ but not FasL- CTLs. In contrast to these results with CD8+ T cells, alloantigen-stimulated FasL- CD4+ T cells proliferate vigorously compared to FasL+ cells. These data demonstrate that reverse signaling through FasL is required for CTLs to achieve maximal proliferation and may provide clues to differences in the homeostatic regu...Continue Reading

References

May 1, 1992·Immunology Today·L A Tartaglia, D V Goeddel
Dec 1, 1993·The Journal of Experimental Medicine·M R AldersonD H Lynch
Feb 2, 1995·Nature·J DheinP H Krammer
Mar 10, 1995·Science·S Nagata, P Golstein
May 5, 1995·Science·C ArpinY J Liu
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Jan 14, 1994·Cell·K A HogquistF R Carbone
Feb 1, 1996·Current Opinion in Genetics & Development·M Tewari, V M Dixit
Mar 1, 1997·Molecular and Cellular Biology·C S DuckettC B Thompson

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Citations

May 15, 2004·Medical Hypotheses·Chris Forden
Dec 31, 2003·Experimental Cell Research·Ming-Jen HsuShie-Liang Hsieh
Oct 14, 2003·Biochemical Pharmacology·Andreas LinkermannOttmar Janssen
Feb 13, 2001·Molecular Immunology·A B AlexandroffD D Taub
Apr 17, 2002·Journal of the American College of Cardiology·Yoshinori SekoRyozo Nagai
Oct 31, 1998·Current Opinion in Immunology·P R WalkerP Y Dietrich
Dec 18, 2002·Cytokine & Growth Factor Reviews·Harald WajantPeter Scheurich
Dec 10, 1998·Nature Medicine·J DesbaratsM K Newell
Oct 2, 2009·Nature·Lorraine A O' ReillyAndreas Strasser
Aug 26, 2006·Nature Reviews. Immunology·Kenneth M MurphyJohn R Sedý
May 11, 2002·Nature Reviews. Immunology·Marcel R M van den Brink, Steven J Burakoff
Jun 9, 2007·Cell Death and Differentiation·V KirkinM Zörnig
Jun 20, 2001·Acta Physiologica Scandinavica·K Nagaraju
Jun 6, 1998·The Journal of Experimental Medicine·H KishimotoJ Sprent
Apr 20, 1999·The Journal of Experimental Medicine·L L HillL B Owen-Schaub
Apr 3, 2002·The Journal of Experimental Medicine·Dietrich ConzeMercedes Rincón
Jul 16, 2003·The Journal of Experimental Medicine·Tamar E Boursalian, Pamela J Fink
Apr 1, 2009·International Immunology·Maren PaulsenOttmar Janssen
Aug 18, 2009·International Immunology·Songwen JuXueguang Zhang
Mar 3, 2010·Rheumatology·Takahiko HoriuchiTerufumi Shimoda
Mar 22, 2001·Transplantation·J TrambleyC P Larsen
Jun 1, 2004·Inflammatory Bowel Diseases·Georg H Waetzig, Stefan Schreiber
Jun 16, 2005·Journal of Pediatric Hematology/oncology·Micha I BankBodil Laub Petersen
Mar 26, 2003·Genes & Development·Leonardo SalmenaRazqallah Hakem
Aug 5, 2008·American Journal of Respiratory Cell and Molecular Biology·Pazit Y CohenShulamit B Wallach-Dayan
Dec 22, 1999·The Journal of Clinical Investigation·J TrambleyC P Larsen
Mar 1, 2006·BMC Immunology·Rebecca LamasonKanneboyina Nagaraju
Dec 31, 2008·Cell Communication and Signaling : CCS·Matthias VossOttmar Janssen

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