Maximal strength training increases muscle force generating capacity and the anaerobic ATP synthesis flux without altering the cost of contraction in elderly

Experimental Gerontology
Ole Kristian BergGwenael Layec

Abstract

Aging is associated with a progressive decline in skeletal muscle function, then leading to impaired exercise tolerance. Maximal strength training (MST) appears to be a practical and effective intervention to increase both exercise capacity and efficiency. However, the underlying physiological mechanisms responsible for these functional improvements are still unclear. Accordingly, the purpose of this study was to examine the intramuscular and metabolic adaptations induced by 8 weeks of knee-extension MST in the quadriceps of 10 older individuals (75 ± 9 yrs) by employing a combination of molecular, magnetic resonance 1H-imaging and 31P-spectroscopy, muscle biopsies, motor nerve stimulation, and indirect calorimetry techniques. Dynamic and isometric muscle strength were both significantly increased by MST. The greater torque-time integral during sustained isometric maximal contraction post-MST (P = 0.002) was associated with increased rates of ATP synthesis from anaerobic glycolysis (PRE: 10 ± 7 mM·min-1; POST: 14 ± 7 mM·min-1, P = 0.02) and creatine kinase reaction (PRE: 31 ± 10 mM·min-1; POST: 41 ± 10 mM·min-1, P = 0.006) such that the ATP cost of contraction was not significantly altered. Expression of fast myosin heavy chain...Continue Reading

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Citations

Apr 8, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ole Kristian BergGwenael Layec
Jul 3, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Runar UnhjemEivind Wang
Jul 21, 2020·European Journal of Sport Science·Gersiel Nascimento de Oliveira JúniorFábio Lera Orsatti
Jul 11, 2020·Lipids in Health and Disease·David W RussStylianos P Scordilis
Apr 20, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Samarita Beraldo SantagnelloFábio Lera Orsatti
Feb 11, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alfredo L Lopez KolkovskyPierre G Carlier
Mar 9, 2021·Frontiers in Physiology·Hans Torvild KittilsenØyvind Støren
May 22, 2021·Geriatric Orthopaedic Surgery & Rehabilitation·Ole Kristian BergEivind Wang
Jul 21, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marcelo A S CarneiroFábio L Orsatti

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