PMID: 6407256Jun 1, 1983Paper

Maximum calorie (sub-threshold) dieting of the obese and its hormonal response

Acta Endocrinologica
T J WilkinD Vannereau

Abstract

Severe calorie restriction for treating the obese reduces serum triiodothyronine (T3) and energy expenditure, and may be counterproductive. In order to avoid severe calorie deficiency, we measured the individual minimum energy requirements (threshold, T) in 17 obese females and fed each on a sub-threshold diet, comprising the maximum number of calories commensurate with weight loss (T-200 cals). Mean T-200 was 1318 +/- 96 cals, but the mean weight loss after 16 weeks on a sub-threshold diet (STD) was identical (17 kg) to that obtained by 22 age-matched female controls on a classical diet of 659 +/- 59 cals, exactly half the intake. Weight loss on the classical diet was initially rapid but decelerated sharply after 8 weeks, while on the sub-threshold diet the rate of loss remained constant throughout. In a second study, thyroid hormone measurements were performed three times weekly in 27 obese females during the 4 week period required to establish T. The mean weight loss was 4.02 +/- 0.3 kg, but T3 levels varied minimally and very transiently. STD produces short-term results similar to those obtained by severe calorie deprivation, but is more acceptable to the patient. It appears not to provoke the fat-saving reflexes provoked b...Continue Reading

Citations

Jan 20, 2010·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·C F O'RiordanT J Wilkin
Mar 1, 1990·The British Journal of Nutrition·N KennedyA A Jackson
Nov 11, 2005·Journal of Psychopharmacology·Richard I G Holt
Jun 26, 2002·Human Fertility : Journal of the British Fertility Society·Jonathan Lord, Terence Wilkin

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