PMID: 9555559Apr 29, 1998Paper

Maximum efficacy of finasteride is obtained within 6 months and maintained over 6 years. Follow-up of the Scandinavian Open-Extension Study. The Scandinavian Finasteride Study Group

European Urology
P Ekman

Abstract

To study the long-term efficacy and safety of the drug finasteride (Proscar) for benign prostatic hyperplasia and to evaluate whether an improved effect beyond 1 year was due to continuous selection of 'responders'. We also wanted to investigate whether drop-outs differed in short-term responses to those completing the trial. A total of 182 patients were enrolled in a double-blind randomized multicenter study with the drug finasteride. After 6 months, all patients were treated with active drug for up to 6 years. Ninety-nine of the patients (54.5%) were still in the trial at its closure. Patients treated with active drug had a decrease in prostate size of around 27% at 6 months, a figure reached by the ex-placebo group at 12 months. At 6 years, both groups had a reduction in prostate size of 21% as measured from baseline. At 6 months, urinary flow had improved by a mean of 2.4 ml/s in the finasteride group and reached an improvement of 2.8 ml/s in the ex-placebo group at 12 months. At 6 years, the flow had improved by 2.2 ml/s in both groups combined as compared to baseline data. The symptom score was improved by 3.4 points in the finasteride group at 6 months and by 2.6 points in the ex-placebo group at 12 months; both values w...Continue Reading

Citations

Jan 15, 2000·Scandinavian Journal of Urology and Nephrology. Supplementum·P Ekman
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Zhang WeihuaJan-Ake Gustafsson

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