Maximum intraoperative elongation of the rat sciatic nerve with tissue expander: functional, neurophysiological, and histological assessment

Microsurgery
Christina M ArnaoutoglouA E Beris

Abstract

The purpose of this study was to assess the maximum rapid intraoperative elongation of the rat sciatic nerve with the use of tissue expander, and its possible functional recovery. One hundred and eight rats were divided into five groups, and their right sciatic nerves were expanded with a 10-cc, 12-cc, 14-cc, 16-cc, and 18-cc expander, respectively, for 1 h. The functional recovery of the nerve was assessed at intervals up to 3 months, using the sciatic function index (SFI), neurophysiological indices, and histology. The maximum intraoperative elongation was observed in group IV (16-cc volume of tissue expander), at about 23.83%. SFI decreased between the first and seventh postoperative days, but gradually recovered, reaching preoperative values in all groups according to the formulas of De Medinaceli et al. (Exp. Neurol. 77:634-643, 1982) and Bain et al. (Plast. Reconstr. Surg. 83:129-136, 1989). Latency and motor conduction velocity demonstrated deterioration after expansion, which peaked after surgery. Recovery was gradually completed by the end of the experiment. The histological findings indicated minor aberrations immediately after expansion and maximal demyelination with axonal disruption on day 15. The reparative proces...Continue Reading

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Citations

Oct 16, 2014·Neural Regeneration Research·Kenneth M VazSameer B Shah
Jul 2, 2011·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Norie KoderaHiromoto Ito
Mar 3, 2017·Journal of Neurophysiology·James M LoveSameer B Shah

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