Maximum lifetime body mass index is the appropriate predictor of knee and hip osteoarthritis

Archives of Orthopaedic and Trauma Surgery
Sabine Patricia SingerMichael C Liebensteiner

Abstract

In light of inconsistencies in the literature, this study aimed to investigate the relationship between obesity (current and historic) and osteoarthritis (OA) of the knee or hip. We examined 99 people (knee OA, hip OA and controls), age > 50 years, in a case-control study. The current weight, height and waist circumference were measured on site, and detailed weight changes over their lifetime were based on questionnaires and standardized interviews. We used binomial logistic regression to determine the predictive value for an osteoarthritis group membership of each derived indicator. An increase in 'maximum-BMI' increased the odds ratio for both knee OA (OR 1.2; CI 1.1-1.4; p = 0.005; R 2 = 0.36) and hip OA (OR 1.2; CI 1.0-1.3; p = 0.027; R 2 = 0.16). Current BMI was significantly associated with knee OA but not with hip OA. A high "minimum-BMI" (over the age of 18 years) had the highest odds ratio of all calculated indicators for both osteoarthritis groups. Based on our findings, it is concluded that the maximum BMI over one's lifespan is a better predictor of OA of the hip or the knee than the current BMI. The knee joint seems to be more sensitive to obesity as current BMI was associated only with knee OA but not with hip OA.

References

Mar 1, 1996·The American Journal of Clinical Nutrition·D T Felson
Jul 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T S HanM E Lean
Nov 14, 2000·Annals of Internal Medicine·D T FelsonV Goldberg
Oct 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M ParkinS S Devesa
May 25, 2006·Journal of the American Dietetic Association·Veronica MontiTed D Adams
Feb 8, 2008·PLoS Medicine·Pieter H M van BaalWerner B F Brouwer
Oct 30, 2008·BMC Medical Research Methodology·Johanna C DekkersWillem van Mechelen
Sep 26, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rajiv GandhiNizar N Mahomed
Dec 2, 2009·Arthritis and Rheumatism·Harry KotlarzJohn A Rizzo
Mar 31, 2015·The American Journal of Medicine·Jos RunhaarSita M A Bierma-Zeinstra
Nov 13, 2015·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·P AmiriJ L Astephen Wilson
Mar 10, 2016·Clinical Biomechanics·Derek N PamukoffJ Troy Blackburn
Jun 18, 2016·Patient Preference and Adherence·Pilar Isla PeraDiana Marre

❮ Previous
Next ❯

Citations

Jan 26, 2020·Archives of Orthopaedic and Trauma Surgery·Jun-Seob SongNam-Hong Choi
Feb 20, 2019·Archives of Orthopaedic and Trauma Surgery·Louis BoycePramod Achan
May 17, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Xingzhong JinNatasha Nassar

❮ Previous
Next ❯

Software Mentioned

SPSS
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique
S GhroubiM H Elleuch
Journal of the European Academy of Dermatology and Venereology : JEADV
S KumarA A Qureshi
© 2022 Meta ULC. All rights reserved