Maximum rate of oxygen uptake by human skeletal muscle in relation to maximal activities of enzymes in the Krebs cycle

The Journal of Physiology
E BlomstrandB Saltin

Abstract

1. Ten subjects performed incremental exercise up to their maximum work rate with the knee extensors of one leg. Measurements of leg blood flow and femoral arteriovenous differences of oxygen were made in order to be able to calculate oxygen uptake of the leg. 2. The volume of the quadriceps muscle was determined from twenty-one to twenty-five computer tomography section images taken from the patella to the anterior inferior iliac spine of each subject. 3. The maximal activities of three enzymes in the Krebs cycle, citrate synthase, oxoglutarate dehydrogenase and succinate dehydrogenase, were measured in biopsy samples taken from the vastus lateralis muscle. 4. The average rate of oxygen uptake over the quadriceps muscle at maximal work, 353 ml min-1 kg-1, corresponded to a Krebs cycle rate of 4.6 mumol min-1 g-1. This was similar to the maximal activity of oxoglutarate dehydrogenase (5.1 mumol min-1 g-1), whereas the activities of succinate dehydrogenase and citrate synthase averaged 7.2 and 48.0 mumol min-1 g-1, respectively. 5. It is suggested that of these enzymes, only the maximum activity of oxoglutarate dehydrogenase can provide a quantitative measure of the capacity of oxidative metabolism, and it appears that the enzym...Continue Reading

References

Apr 1, 1991·Journal of Applied Physiology·R M McAllister, R L Terjung
May 1, 1985·Pflügers Archiv : European journal of physiology·H ReichmannD Pette
Sep 1, 1985·The Journal of Physiology·P Andersen, B Saltin
Nov 1, 1985·Journal of Applied Physiology·P AndersenB Saltin
Oct 1, 1973·The American Journal of Physiology·K M BaldwinJ O Holloszy
Jan 1, 1983·Annual Review of Physiology·C G Blomqvist, B Saltin
Feb 1, 1983·The Journal of Physiology·D G Allen, C H Orchard
Apr 1, 1981·Respiration Physiology·C R Taylor, E R Weibel
Dec 15, 1981·The Biochemical Journal·G J CooneyE A Newsholme
Oct 1, 1994·Journal of Applied Physiology·D M RobinsonR L Terjung

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Citations

Aug 26, 2000·Progress in Biophysics and Molecular Biology·R Bottinelli, C Reggiani
Aug 31, 2001·Biophysical Chemistry·B Korzeniewski, J A Zoladz
Oct 5, 2001·Journal of the American College of Cardiology·B MettauerR Ventura-Clapier
Nov 12, 2002·Respiratory Physiology & Neurobiology·Brad J BehnkeDavid C Poole
Apr 14, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jan J KaczorJerzy Popinigis
Feb 15, 2000·Annals of the New York Academy of Sciences·K F Sheu, J P Blass
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·J SauledaA G Agustí
Dec 22, 2004·Pediatric Research·Jan J KaczorMark A Tarnopolsky
Sep 27, 2005·Sports Medicine·Chris R Abbiss, Paul B Laursen
Mar 26, 2009·Sports Medicine·François Billaut, David Bishop
Mar 12, 2009·Journal of Inherited Metabolic Disease·V ValayannopoulosP de Lonlay
Jul 6, 2010·European Journal of Applied Physiology·T van WesselR T Jaspers
Feb 2, 2016·Free Radical Biology & Medicine·Zsolt RadakErika Koltai
Jul 23, 2015·International Journal for Numerical Methods in Biomedical Engineering·Paulo Roberto TrenhagoRaúl Antonino Feijóo
Apr 15, 2003·The Journal of Physiology·Brad J BehnkeDavid C Poole
May 29, 2012·Experimental Physiology·Robert A JacobsCarsten Lundby
Sep 30, 2003·The Journal of Physiology·Sharon A JubriasKevin E Conley
Oct 4, 2011·Progress in Neurobiology·Thomas Seifert, Niels H Secher
Apr 21, 2011·Experimental Gerontology·Ninna IversenHenriette Pilegaard
Dec 15, 2010·Mitochondrion·Robert BoushelBengt Saltin
May 27, 2009·The International Journal of Biochemistry & Cell Biology·Erich Gnaiger
Jan 17, 2009·Respiratory Physiology & Neurobiology·Nicolas BourdillonJean-Paul Richalet
Jun 15, 2007·Biophysical Chemistry·Bernard Korzeniewski
Jun 5, 2007·Experimental Physiology·Richard A Howlett, Michael C Hogan
Nov 22, 2015·Scandinavian Journal of Medicine & Science in Sports·M NybergY Hellsten
Oct 4, 2012·The International Journal of Biochemistry & Cell Biology·Robert Boushel, Bengt Saltin
Nov 5, 2013·Biochimica Et Biophysica Acta·Steen LarsenJørn W Helge
Aug 1, 2014·Acta histochemica·Anabelle S CornachioneAna Claudia Mattiello-Sverzut

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