May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for?

Journal of Molecular and Cellular Cardiology
Kristine Y DeLeon-Pennell

Abstract

In a recent issue of Journal of Molecular and Cellular Cardiology, George et al. [1] identified discoidin domain receptor 2 (DDR2) as a positive modulator of collagen production in cardiac fibroblasts stimulated with angiotensin II (Ang II). DDR2 is a tyrosine kinase collagen receptor and is associated with pathological scarring of multiple organs; nevertheless, the functional role of DDR2 in the myocardium remains unclear. George et al. present evidence for the first time that Ang II induces cardiac fibrosis by enhancing DDR2 expression in cardiac fibroblasts via p38 mitogen activated protein kinase (p38 MAPK)-mediated activation of nuclear factor-κB (NF-κB).

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Citations

Jun 29, 2016·Cell and Tissue Research·Nuno Miranda Coelho, Christopher A McCulloch
Oct 28, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Malina J Ivey, Michelle D Tallquist
Apr 14, 2018·American Journal of Respiratory Cell and Molecular Biology·Shijing JiaKevin K Kim
Mar 15, 2020·Heart Failure Reviews·Bianca Olivia Cojan-MinzatLucia Agoston-Coldea

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