Mazindol effects on schedule-controlled responding of the pigeon

European Journal of Pharmacology
J D Leander, D E McMillan

Abstract

The effects of mazindol, a non-phenethylamine anorexic, were determined in pigeons key pecking under a multiple fixed-ratio 30 response, fixed-interval 5 min schedule of food presentation. The low average rates of responding under the fixed-interval schedule were greatly increased (from 0.7 response/sec to 2 responses/sec) at doses from 0.1 to 10 mg/kg. The higher rates of responding under the fixed-ratio schedule were only decreased by increasing doses of mazindol. Throughout the fixed interval, mazindol tended to produce a constant rate of responding completely disrupting the normal, positively accelerated pattern of responding. These rate-increasing effects of mazindol were much greater than those of phenethylamines tested under similar conditions. The large increases in rates of responding under the fixed-interval component were discussed in terms of the known biochemical effects of mazindol.

References

Feb 11, 1977·Science·F A Gonzalez, L D Byrd
Feb 1, 1976·Pharmacology, Biochemistry, and Behavior·M C Wilson, C R Schuster
Apr 21, 1977·European Journal of Pharmacology·M F SugrueK G Charlton
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May 10, 1957·Science·R J HERRNSTEIN, W H MORSE

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Citations

Jul 1, 1979·European Journal of Pharmacology·L D Byrd
Nov 1, 1981·Pharmacology, Biochemistry, and Behavior·S A SegalD M Thompson
Jul 8, 1989·Lancet·J H JaffeJ L Katz

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