MBL2 genetic screening in patients with recurrent vaginal infections

American Journal of Reproductive Immunology : AJRI
Michele MilaneseSergio Crovella

Abstract

Mannose-binding lectin (MBL) is an important component of the innate immunity, present at the mucosal level in vagina: a common pathogen's entry point. We used a rapid genotyping method based on melting temperature assay to search for three single nucleotide polymorphisms (SNPs) located in the first exon of the MBL2 gene and we also measured MBL serum levels in patients with recurrent bacterial vaginosis (rBV) and recurrent vulvovaginal candidiasis (rVVC). Detected frequencies of MBL2 SNPs were comparable to the ones already reported for the Italian population and no significant differences were found between rVVC, rBV and controls. MBL serum levels did not show significant differences between the studied groups. No correlation for the screened mutations has been found neither in protecting nor in favoring the infection in rVVC and rBV patients. Our data demonstrate a lack of association between functional polymorphisms in the first exon of MBL2 gene, MBL deficiency, VVC and rBV.

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Citations

Sep 30, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G DondersD Janssens
Jan 29, 2013·Current Infectious Disease Reports·Martin JaegerMihai G Netea
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay RamPeter A Rice
Jul 16, 2013·PLoS Pathogens·Antonella De LucaLuigina Romani
Feb 13, 2016·Jundishapur Journal of Microbiology·Maryam MoslemAlireza Kheradmand
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Oct 16, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Agostinho CarvalhoLuigina Romani
Jan 25, 2020·Microorganisms·Diletta RosatiMihai G Netea
Mar 19, 2020·Frontiers in Cellular and Infection Microbiology·Richard M Merkhofer, Bruce S Klein
May 9, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ji-Yun TianXin-Zheng Li

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