MC-LR induces dysregulation of iron homeostasis by inhibiting hepcidin expression: A preliminary study

Chemosphere
Jinxia WuXinghai Chen

Abstract

The liver is an important iron storage site and a primary MC-LR target. C57BL/6 and Hfe-/- mice were used to investigate effects and mechanisms of MC-LR on systematic iron homeostasis. Body weight, tissue iron content, hematological and serological indexes, and histopathological were evaluated. Ultrastructure and iron metabolism-related genes and proteins were analyzed. MC-LR induced dose-dependent increases in red blood cells, hemoglobin, and hematocrit. In contrast MC-LR-induced dose-dependent decreases in mean corpuscular volume, hemoglobin, and hemoglobin concentration were observed both C57BL/6 and Hfe-/- mice. In both mouse species, serological indexes increased. Aggravated liver and spleen iron were observed in C57BL/6 mice, consistent with Perls' Prussian blue staining. However, an opposite trend was observed in Hfe-/- mice. C57BL/6 mice had lower Hamp1 (Hepcidn), Bmp6, Il-6, and Tmprss6. Significant increased Hjv, Hif-1α and Hif-2α were observed in both C57BL/6 and Hfe-/- mice. MC-LR-induced pathological lesions were dose-dependent increase in C57BL/6 mice. More severe pathological injuries in MC-LR groups (25 μg/kg) were observed in Hfe-/- mice than in C57BL/6 mice. In Hfe-/- mice, upon exposure to 25 μg/kg MC-LR, mit...Continue Reading

Citations

Dec 15, 2019·International Journal of Environmental Research and Public Health·Xiping YiAnd Fei Yang
Feb 23, 2021·Environmental Research·Linjia ShiHuizhen Zhang
Jun 3, 2021·Environment International·Ya MaHuizhen Zhang

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