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MCAM abnormal expression and clinical outcome associations are highly cancer dependent as revealed through pan-cancer analysis

Briefings in Bioinformatics

Mar 1, 2019

Yunxia AnXiaoju Zhang

Abstract

MCAM (CD146) is a cell surface adhesion molecule that has been reported to promote cancer development, progression and metastasis and is considered as a potential tumor biomarker and therapeutic target. However, inconsistent reports exist, and its clinical value is yet to be confirmed. ...read more

Mentioned in this Paper

Biological Markers
MCAM gene
Biochemical Pathway
Genome
Primary Neoplasm
Neoplasms
MCAM protein, human
Pharmacologic Substance
Cell Surface
Tumor Cells, Malignant
1
1
Paper Details
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MCAM abnormal expression and clinical outcome associations are highly cancer dependent as revealed through pan-cancer analysis

Briefings in Bioinformatics

Mar 1, 2019

Yunxia AnXiaoju Zhang

PMID: 30815677

DOI: 10.1093/bib/bbz019

Abstract

MCAM (CD146) is a cell surface adhesion molecule that has been reported to promote cancer development, progression and metastasis and is considered as a potential tumor biomarker and therapeutic target. However, inconsistent reports exist, and its clinical value is yet to be confirmed. ...read more

Mentioned in this Paper

Biological Markers
MCAM gene
Biochemical Pathway
Genome
Primary Neoplasm
Neoplasms
MCAM protein, human
Pharmacologic Substance
Cell Surface
Tumor Cells, Malignant
1
1

Similar Papers Found In These Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine

MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and MedicineMay 23, 2012
Zheng WuZhigang Zhang
Paper Details
References
  • References30
  • Citations
123
  • References30
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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