MCEE: a data preprocessing approach for metabolic confounding effect elimination

Analytical and Bioanalytical Chemistry
Yitao LiTianlu Chen

Abstract

It is well recognized that physiological and environmental factors such as race, age, gender, and diurnal cycles often have a definite influence on metabolic results that statistically manifests as confounding variables. Currently, removal or controlling of confounding effects relies heavily on experimental design. There are no available data processing techniques focusing on the compensation of their effects. We therefore proposed a new method, Metabolic confounding effect elimination (MCEE), to remove the influence of specified confounding factors and make the data more accurate. The method consists of three steps: metabolites grouping, confounder-related metabolites selection, and metabolites modification. Its effectiveness and advantages were evaluated comprehensively by several simulated models and real datasets, and were compared with two typical methods, the principal component analysis (PCA)- and the direct orthogonal signal correction (DOSC)-based methods. MCEE is simple, effective, and safe, and is independent of sample number, association degree, and missing value. Hence, it may serve as a good complement to existing metabolomics data preprocessing methods and aid in better understanding the metabolic and biological ...Continue Reading

References

Mar 29, 2001·Annual Review of Public Health·S Greenland, H Morgenstern
Feb 25, 2003·Occupational and Environmental Medicine·R McNamee
Oct 24, 2003·The New England Journal of Medicine·Robert A Terkeltaub
Nov 27, 2004·Psychosomatic Medicine·Nicholas J S ChristenfeldSander Greenland
Mar 2, 2005·Nature Reviews. Immunology·Barbara Rehermann, Michelina Nascimbeni
Jul 6, 2006·Arthritis Research & Therapy·Kenneth G Saag, Hyon Choi
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yan MaLan Guo
Apr 24, 2007·Lancet·Jürgen Braun, Joachim Sieper
Nov 6, 2007·Kidney International·K J JagerF W Dekker
Sep 17, 2009·Journal of Proteome Research·Frans M van der KloetRenger H Jellema
Jan 5, 2010·Nature Reviews. Rheumatology·Robert Terkeltaub
Sep 28, 2010·Lancet·David L ScottTom W J Huizinga
Dec 31, 2010·International Journal of Cancer. Journal International Du Cancer·Jie WeiWei Jia
Apr 27, 2011·Molecular & Cellular Proteomics : MCP·Tianlu ChenWei Jia
Jun 20, 2012·Essays in Biochemistry·Mitsuo Yamauchi, Marnisa Sricholpech
Jan 25, 2013·Nature Reviews. Cancer·Alla ArzumanyanMark A Feitelson
Jul 4, 2013·Journal of Proteome Research·Miao JiangAiping Lu
Aug 19, 2014·Journal of Proteome Research·Guoxiang XieWeiping Jia
Sep 26, 2014·Metabolomics : Official Journal of the Metabolomic Society·Steven C MooreAmanda J Cross
Jan 13, 2015·Journal of Proteome Research·Guoxiang XieWei Jia
Apr 12, 2016·Scientific Reports·Xiaojiao ZhengWei Jia
Sep 30, 2016·European Journal of Clinical Nutrition·F-C Tang, C-C Chan
Jul 5, 2017·Clinical Pharmacology and Therapeutics·Guoxiang XieWei Jia
Nov 2, 2017·Journal of Proteome Research·Alessia VignoliEdoardo Saccenti

❮ Previous
Next ❯

Citations

Jul 7, 2019·Analytical and Bioanalytical Chemistry·Yitao LiTianlu Chen
Nov 18, 2018·Electrophoresis·Biswapriya B Misra, Subhashree Mohapatra
Oct 23, 2019·Analytical Chemistry·Dandan LiangTianlu Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Methods in Molecular Biology
Matthias Scholz, Joachim Selbig
Chemometrics and Intelligent Laboratory Systems : an International Journal Sponsored by the Chemometrics Society
Imhoi KooXiang Zhang
Scandinavian Journal of Clinical and Laboratory Investigation
Leslie R EucedaTone F Bathen
Computational and Structural Biotechnology Journal
Jörg BartelFabian J Theis
© 2022 Meta ULC. All rights reserved