MCG101-induced cancer anorexia-cachexia features altered expression of hypothalamic Nucb2 and Cartpt and increased plasma levels of cocaine- and amphetamine-regulated transcript peptides

Oncology Reports
Jonathan R BurgosUlrika Smedh

Abstract

The aim of the present study was to explore central and peripheral host responses to an anorexia-cachexia producing tumor. We focused on neuroendocrine anorexigenic signals in the hypothalamus, brainstem, pituitary and from the tumor per se. Expression of mRNA for corticotropin-releasing hormone (CRH), cocaine- and amphetamine-regulated transcript (CART), nesfatin-1, thyrotropin (TSH) and the TSH receptor were explored. In addition, we examined changes in plasma TSH, CART peptides (CARTp) and serum amyloid P component (SAP). C57BL/6 mice were implanted with MCG101 tumors or sham-treated. A sham-implanted, pair‑fed (PF) group was included to delineate between primary tumor and secondary effects from reduced feeding. Food intake and body weight were measured daily. mRNA levels from microdissected mouse brain samples were assayed using qPCR, and plasma levels were determined using ELISA. MCG101 tumors expectedly induced anorexia and loss of body weight. Tumor-bearing (TB) mice exhibited an increase in nesfatin-1 mRNA as well as a decrease in CART mRNA in the paraventricular area (PVN). The CART mRNA response was secondary to reduced caloric intake whereas nesfatin-1 mRNA appeared to be tumor-specifically induced. In the pituitary,...Continue Reading

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Citations

Sep 16, 2017·European Journal of Preventive Cardiology·Louise G Shewan
Jan 25, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Jennifer L JuengelPeter D Johnstone
May 20, 2017·World Journal of Gastroenterology : WJG·Guo-Tao YangAi-Qin Dong
Oct 25, 2020·Proteomics. Clinical Applications·Ai-Jun GuoA-Man Xu
Jun 3, 2021·International Journal of Molecular Sciences·Anna SkorupskaDominika Bystranowska

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