PMID: 1206760Dec 1, 1975Paper

Mchanisms of antitumor action of Corynebacterium parvum: nonspecific tumor cell destruction at site of immunologically mediated sensitivity reaction to C. parvum

Journal of the National Cancer Institute
R L Tuttle, R J North

Abstract

Mice immunized in the footpad with Corynebacterium parvum developed a systemic mechanism with a potential for destroying syngeneic tumor cells. The development of this mechanism of antitumor action depended on the generation of a state of systemic sensitivity to C. parvum antigens, which allowed an immunologically mediated inflammatory response to be focused at the site of a tumor cell challenge or in the bed of an established tumor. This resulted in complete inhibition of growth of the former regression of the latter. This nonspecific mechanism of tumor cell destruction could be utilized only during a relatively short period when mice were responding maximally to the organism. This corresponded to a period during which there was maximum cell division in the lymph node draining the site of immunization with C. parvum, maximum systemic macrophage activation, and maximum sensitivity to eliciting injections of the organism. The potential for destroying tumor cells could be transferred to normal recipients with lymph node cells from C. parvum-immunized donors, which indicated the distinct possibility that antitumor action was based on the cell-mediated response to C. parvum antigens. That the destruction of tumor cells at the site ...Continue Reading

Citations

Nov 15, 1979·International Journal of Cancer. Journal International Du Cancer·G L Bartlett, J W Kreider
Sep 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G ClaeysR Pauwels
Jan 1, 1980·Journal of Immunopharmacology·R MegirianL D Loose
Sep 30, 1991·International Journal of Cancer. Journal International Du Cancer·I BursukerL S Keller
Jul 19, 2013·BioMed Research International·Natalie FischerHolger Brüggemann
Mar 1, 1977·Infection and Immunity·G WolbergJ K Whisnant
Oct 1, 1977·Infection and Immunity·M S PineiroM I Bull

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