PMID: 8614239Mar 3, 1995Paper

MCI-154 activates the Ca(2+)-activated K+ channel of vascular smooth muscle cells

Life Sciences
H MiyoshiM Nomura

Abstract

The aim of this study was to examine the effects of MCI-154, a new positive inotropic agent with vasodilating properties, on the Ca2+-activated K+ channel (KCa channel) of vascular smooth muscle cells. Cultured smooth muscle cells from a porcine coronary artery were studied using the patch-clamp technique. Extracellular application of 100 microM MCI-154 activated the KCa channel in intact cell-attached patch configurations. In excised inside-out patch configurations, application of 100 microM MCI-154 to the cytosolic side activated the KCa channel directly, suggesting that the Ca2+ sensitivity of the KCa channel itself is modulated. Though extracellular application of 100 microM amrinone, a phosphodiesterase inhibitor, activated the KCa channel in the cell-attached patch configurations, application of 100 microM amrinone to the cytosolic side could not activate the KCa channel in inside-out patch configurations. These results indicate that different from amrinone, MCI-154 can modulate Ca2+ sensitivity of the KCa channel in vascular smooth muscle cells.

References

Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth

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Citations

Mar 30, 2005·International Anesthesiology Clinics·Young Lan Kwak

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