MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression

BMC Cancer
Zhikun LiuShusen Zheng

Abstract

Minichromosome Maintenance family (MCMs), as replication licensing factors, is involved in the pathogenesis of tumors. Here, we investigated the expression of MCMs and their values in hepatocellular carcinoma (HCC). MCMs were analyzed in 105 samples including normal livers (n = 15), cirrhotic livers (n = 40), HCC (n = 50) using quantitative polymerase chain reaction (qPCR) (Cohort 1). Significantly up-regulated MCMs were verified in 102 HCC and matched peritumoral livers using PCR (Cohort 2), and the correlations with clinical features and outcomes were determined. In addition, the focused MCMs were analyzed in parallel immunohistochemistry of 345 samples on spectrum of hepatocarcinogenesis (Cohort 3) and queried for the potential specific role in cell cycle. MCM2-7, MCM8 and MCM10 was significantly up-regulated in HCC in Cohort 1. In Cohort 2, overexpression of MCM2-7, MCM8 and MCM10 was verified and significantly correlated with each other. Elevated MCM2, MCM6 and MCM7 were associated with adverse tumor features and poorer outcomes. In Cohort 3, MCM6 exhibited superior HCC diagnostic performance compared with MCM2 and MCM7 (AUC: 0.896 vs. 0.675 and 0.771, P < 0.01). Additionally, MCM6 other than MCM2 and MCM7 independently pr...Continue Reading

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Mar 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Susan L Forsburg
Feb 24, 2006·Current Opinion in Cell Biology·Domenico MaioranoMarcel Méchali
Apr 25, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Alberto QuagliaAmar Dhillon
Jun 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Douglas I LinJ Alan Diehl
Jul 2, 2009·International Journal of Cancer. Journal International Du Cancer·Wenjun ChangGuangwen Cao
Jul 13, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Yan-Ming ZhouZheng-Feng Yin
Aug 25, 2012·Sub-cellular Biochemistry·Sriram Vijayraghavan, Anthony Schwacha
Jan 24, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tenghao ZhengYuxiu Yang
Jan 25, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Aladim Gomes LameiraDécio Dos Santos Pinto
Apr 8, 2014·The International Journal of Biological Markers·Sérgio Menezes Amaro FilhoAlcina F Nicol
Oct 14, 2014·International Journal of Oncology·Xiyan XiaoYanping Zhang
Dec 2, 2014·The Journal of Clinical Investigation·Saleh AlAsiriAleksandar Rajkovic
Jan 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sanaa EissaNada O E Essawy
Jan 23, 2015·Journal of Experimental & Clinical Cancer Research : CR·Xiao XuShusen Zheng
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Mar 19, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrizia ZavattariAmedeo Columbano
Apr 17, 2015·BMC Cancer·Caecilia Hapsari Ceriapuri SukowatiClaudio Tiribelli
May 28, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Charlène VigourouxGuillaume Gauchotte
Jul 30, 2015·Nature·Ningning LiNing Gao
Aug 21, 2015·Cancer Science·Shinya TaneYoshimasa Maniwa

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Citations

Jun 30, 2019·Expert Review of Molecular Diagnostics·Shinichi UmedaYasuhiro Kodera
Dec 5, 2019·Cancer Chemotherapy and Pharmacology·Lianbao YeWeiqiang Chen
Mar 18, 2020·Cancers·Adewale Oluwaseun FadakaAshwil Klein
Apr 17, 2018·Molecular Medicine Reports·Long-Ci Sun, Hai-Xin Qian
Jan 22, 2020·Cancer Gene Therapy·Liang QuanChaozeng Si
Feb 25, 2020·Analytical Cellular Pathology (Amsterdam)·Si YuYang Chen
Nov 20, 2020·Electromagnetic Biology and Medicine·Zhen DingShuicai Wu
Feb 21, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tian ZengJuan Zou
Aug 22, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Yifei WangWei Kang
May 12, 2018·Journal of Proteome Research·Jing YangXuechuan Hong
Sep 21, 2021·Drug Delivery and Translational Research·Ahmad Reza FarmaniNima Rezaei
Dec 18, 2021·Experimental and Therapeutic Medicine·Xing-Hua LiangHai-Lin Lu

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Methods Mentioned

BETA
PCR
flow cytometry

Software Mentioned

SPSS

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