Mcm1p binding sites in the ARG1 promoter positively regulate ARG1 transcription and S. cerevisiae growth in the absence of arginine and Gcn4p

Amino Acids
Suntaek Hong, Sungpil Yoon

Abstract

In this study, we investigated the activating role of Mcm1p at ARG1 during arginine starvation. Our results showed that two Mcm1p binding sites positively contribute to ARG1 transcription and cell growth. Especially, we provide strong evidence that the Mcm1p binding sites play a positive role in ARG1 transcription to overcome arginine starvation in the absence of Gcn4p. In addition, we found that the Mcm1p binding sites are not only regulated by the presence or absence of arginine but also in the presence or absence of other amino acids. These findings suggest that the ARG1 promoter utilizes different DNA elements to control transcription, depending on which amino acids are detected in the medium.

References

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Feb 24, 2009·Biochemical and Biophysical Research Communications·Sungpil Yoon, Alan G Hinnebusch

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Citations

Mar 16, 2012·Genetics·Per O Ljungdahl, Bertrand Daignan-Fornier
Nov 15, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sungpil YoonSuk Woo Nam

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