MCP-1 production in temporomandibular joint inflammation

Journal of Dental Research
Naomi OguraToshirou Kondoh

Abstract

Synovitis, which is characterized by the infiltration of inflammatory cells, often accompanies progression of temporomandibular joint disorder (TMD) symptoms. Because IL-1β is elevated in synovial fluids obtained from TMDs, we hypothesized that IL-1β-responsive genes in synoviocytes may help identify the putative genes associated with synovitis. Using microarray analysis, we found that monocyte chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1β-stimulated synoviocytes. MCP-1 is a member of the chemokine superfamily. The production of MCP-1 was increased in synoviocytes treated with IL-1β. When IL-1β was injected into the cavities of rat TMJs, inflammatory cells and MCP-1-positive cells were detected in the synovial tissues. Furthermore, MCP-1 levels were higher in synovial fluids from individuals with pain compared with those without pain. Inhibitors of MAP-kinases and NF-κB reduced IL-1β-induced MCP-1 production. These results suggest that MCP-1 stimulated by IL-1β is one of the factors associated with the inflammatory progression of TMDs.

References

Sep 1, 1992·The Journal of Clinical Investigation·A E KochR M Strieter
Apr 1, 1995·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·F R CarlsW Engelke
Mar 21, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·T TakahashiR Suzuki
Sep 12, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·P AlstergrenS Kopp
May 18, 1999·Rheumatology·G SteinerJ S Smolen
May 16, 2000·Journal of Leukocyte Biology·C WeberH W Ziegler-Heitbrock
Aug 24, 2001·International Journal of Oral and Maxillofacial Surgery·H SakamakiH Nagura
Jun 29, 2002·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Makiko TobeHideaki Nagura
Aug 23, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Naomi OguraHideaki Nagura
Jun 17, 2003·Acta Orthopaedica Scandinavica·Balázs BorsiczkyElizabeth Röth
Sep 25, 2003·International Journal of Oral and Maxillofacial Surgery·R KardelA Holmlund
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthias PiererDiego Kyburz
Sep 3, 2005·The Journal of Clinical Investigation·Yumei ZhanPeter Oettgen
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fletcher A WhiteRichard J Miller
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiva ShahraraRichard M Pope
Oct 25, 2008·Biochemical and Biophysical Research Communications·Min-Chul ChoDo-Young Yoon

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Citations

Oct 15, 2013·Neuroscience Letters·John M Dawes, Stephen B McMahon
Mar 20, 2012·Journal of Dental Research·X D WangY H Zhou
Oct 31, 2013·Dento Maxillo Facial Radiology·J SchillingL H S Cevidanes
Jun 22, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yue XuChen Xi
Jun 1, 2013·The Journal of Pain : Official Journal of the American Pain Society·Hong ChenWilliam Maixner
Nov 1, 2011·The Journal of Pain : Official Journal of the American Pain Society·Anne E SandersGary D Slade
Aug 2, 2013·Diagnostic Cytopathology·Toshinari MikamiYasunori Takeda
Jan 29, 2016·Fundamental & Clinical Pharmacology·María Llorián-SalvadorLuis Menéndez
Mar 7, 2015·Journal of Dental Research·X D WangY H Zhou
Nov 8, 2018·Scandinavian Journal of Immunology·Kurt ArkestålOla Winqvist
Apr 2, 2019·Biological & Pharmaceutical Bulletin·Miho Ibi
Feb 28, 2020·International Journal of Molecular Sciences·Yeon-Hee LeeIl Keun Kwon
Nov 12, 2015·BMC Veterinary Research·Aline Ambrogi Franco PradoDurvanei Augusto Maria
Jul 31, 2021·International Journal of Oral Science·Mayank ShrivastavaLiang Ye

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Methods Mentioned

BETA
PCR

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