MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis

Renal Failure
Nesrin BesbasFatih Ozaltin

Abstract

Monocyte chemoattractant protein-1 (MCP-1) is a highly specific chemokine for monocytes and plays roles in pathogenesis of various renal diseases. The aim of this study is to investigate the effect of MCP1 2518 A/G polymorphism on the incidence and clinical course of focal segmental glomerulosclerosis (FSGS) in children. MCP1 2518 A/G genotype was identified by PCR-RFLP in 60 biopsy-proven FSGS patients, 76 steroid sensitive nephrotic syndrome (SSNS) patients, and 96 healthy children. MCP-1 levels in urine and serum were measured by ELISA in all patients and the correlations of genotype with MCP-1 levels and clinical outcome were evaluated. The genotype frequencies for MCP1 were similar in all groups. The percentage of patients who develop chronic renal failure was higher in patients with AA allele compared to GA or GG alleles (46% vs. 35% respectively, p < 0.01, Odds ratio: 1.59). Serum MCP-1 levels were similar in all groups, whereas urinary MCP-1 levels of the patients with FSGS (1680 pg/mg creatinine) were significantly higher than that of patients with SSNS (365 pg/mg creatinine, p < 0.05) and healthy controls (348 pg/mg creatinine; p < 0.05). Urinary MCP-1 levels were correlated with the degree of proteinuria in FSGS grou...Continue Reading

References

Jul 21, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D C Cattran, P Rao
Jun 11, 1999·Biochemical and Biophysical Research Communications·B H RovinR Saxena
Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C J BurtonK P Harris
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hyun Lee KimYo Su Kim
Aug 29, 2003·Lancet·Allison A Eddy, Jordan M Symons
Oct 9, 2003·Kidney International·Ji Hoon KimHyun Soon Lee
Feb 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Oliver M SteinmetzRolf A K Stahl
Feb 18, 2005·Journal of the American Society of Nephrology : JASN·Stéphan TroyanovUNKNOWN Toronto Glomerulonephritis Registry Group
Jan 6, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Debbie S GipsonDavid B Thomas
May 8, 2009·American Journal of Physiology. Renal Physiology·Eun Young LeeSheldon Chen
Oct 8, 2009·Human Molecular Genetics·Eduardo MachucaCorinne Antignac
Jul 17, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Amita YadavSarika Arora
Nov 3, 2010·Scandinavian Journal of Urology and Nephrology·Anna WasilewskaZbigniew Kołodziejczyk
Nov 27, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rasheed GbadegesinMichelle Winn
Aug 20, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Min Jeong Kim, Frederick W K Tam
Sep 13, 2012·European Journal of Pediatrics·Betti Schaefer, Elke Wühl
Feb 12, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kenji IshikuraUNKNOWN Committee of Measures for Pediatric CKD of Japanese Society of Pediatric Nephrology
Jul 23, 2014·Journal of Receptor and Signal Transduction Research·Ning SuTian-Biao Zhou
Jan 31, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Sahar A Fathallah-ShaykhCraig S Wong

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Citations

Aug 16, 2017·Disease Markers·Kinga MusiałDanuta Zwolińska
Aug 16, 2018·International Urology and Nephrology·Song Mao, Liangxia Wu
Dec 18, 2020·Frontiers in Medicine·Manuel Alfredo Podestà, Claudio Ponticelli
Mar 19, 2021·KI Reports·Shipra AgrawalUNKNOWN Pediatric Nephrology Research Consortium

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