MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment

Antimicrobial Agents and Chemotherapy
Racha BeyrouthyRichard Bonnet

Abstract

The spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France.

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Citations

Jan 31, 2018·Antimicrobial Agents and Chemotherapy·André BirgyStéphane Bonacorsi
Jul 24, 2018·Microbial Genomics·Hayley Wilson, M Estée Török
Feb 16, 2018·Clinical Microbiology Reviews·Jesús Rodríguez-BañoAlvaro Pascual
Apr 19, 2018·Animal Health Research Reviews·Jian SunJun Lin
May 21, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Delphine GirlichThierry Naas
May 28, 2019·Critical Reviews in Microbiology·Sue C NangTony Velkov
Jan 12, 2019·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Lucie Bardet, Jean-Marc Rolain
May 28, 2019·The Journal of Antimicrobial Chemotherapy·Saoussen OueslatiThierry Naas

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