PMID: 9188094Mar 1, 1997Paper

Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade

Molecular Biology of the Cell
K ShiozakiP Russell

Abstract

Spc1 in Schizosaccharomyces pombe is a member of the stress-activated protein kinase family, an evolutionary conserved subfamily of mitogen-activated protein kinases (MAPKs). Spc1 is activated by a MAPK kinase homologue, Wis1, and negatively regulated by Pyp1 and Pyp2 tyrosine phosphatases. Mutations in the spc1+ and wis1+ genes cause a G2 cell cycle delay that is exacerbated during stress. Herein, we describe two upstream regulators of the Wis1-Spc1 cascade. wik1+ (Wis1 kinase) was identified from its homology to budding yeast SSK2, which encodes a MAPKK kinase that regulates the HOG1 osmosensing pathway. Delta wik1 cells are impaired in stress-induced activation of Spc1 and show a G2 cell cycle delay and osmosensitive growth. Moreover, overproduction of a constitutively active form of Wik1 induces hyperactivation of Spc1 in wis1(+)-dependent manner, suggesting that Wik1 regulates Spc1 through activation of Wis1. A mutation of mcs4+ (mitotic catastrophe suppressor) was originally isolated as a suppressor of the mitotic catastrophe phenotype of a cdc2-3w wee1-50 double mutant. We have found that mcs4- cells are defective at activation of Spc1 in response to various forms of stress. Epistasis analysis has placed Mcs4-upstream of...Continue Reading

References

Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S OttilieR L Erikson
Mar 19, 1993·Science·J L BrewsterM C Gustin
Oct 22, 1993·Science·I M Ota, A Varshavsky

❮ Previous
Next ❯

Citations

Sep 25, 2001·Trends in Cell Biology·A K Pearce, T C Humphrey
Jun 17, 1998·Molecular Biology of the Cell·K ShiozakiP Russell
Jun 1, 2002·Microbiology and Molecular Biology Reviews : MMBR·Stefan Hohmann
Jul 16, 2003·Molecular and Cellular Biology·Hisashi Tatebe, Kazuhiro Shiozaki
Aug 10, 2005·Eukaryotic Cell·Miguel A Rodríguez-Gabriel, Paul Russell
Jan 13, 2006·Molecular Biology of the Cell·Victoria MartínPaul Russell
Oct 16, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Masayuki Yamamoto
Oct 14, 2011·The Journal of Biological Chemistry·Jill CheethamJanet Quinn
Feb 13, 2013·BMC Microbiology·Marisa MadridJosé Cansado
Oct 18, 2006·Molecular Genetics and Genomics : MGG·Ana P VivancosElena Hidalgo
Apr 27, 2002·Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme·Shinri TamuraTakayasu Kobayashi
Aug 4, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Yuriko Harigaya, Masayuki Yamamoto
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jen-Yu HungPo-Lin Kuo
Dec 18, 2004·Mutation Research·Aminah Ikner, Kazuhiro Shiozaki
Jun 26, 2015·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Lingling HuTomoyuki Furuyashiki
Nov 21, 2013·Communicative & Integrative Biology·Susumu Morigasaki, Kazuhiro Shiozaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.