MD-2 is required for the full responsiveness of mast cells to LPS but not to PGN

Biochemical and Biophysical Research Communications
Hiroko UshioHideoki Ogawa

Abstract

To address the role played by MD-2 in mast cell recognition of LPS, we examined bone marrow-derived mast cells (BMMCs) from MD-2 gene-targeted mice. BMMCs from MD-2-/- mice showed impaired cytokine production (TNF-alpha, IL-6, IL-13, and IL-1beta) in response to LPS from Escherichia coli, but not to peptidoglycan (PGN) from Staphylococcus aureus. In a mast cell-dependent acute septic model, MD-2 deficiency of mast cell resulted in significantly higher mortality due to defective neutrophil recruitment and the production of cytokines in the peritoneal cavity, which was similar to mice with TLR4-deficient mast cells. The TLR2-dependent activation of skin mast cells by PGN was not altered by the absence of MD-2 in vivo. Collectively, MD-2 is essential for the recognition of LPS by TLR4 but not for that of PGN by TLR2 of mast cells.

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Citations

Jul 14, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jaciel Medina-TamayoClaudia González-Espinosa
Jun 13, 2013·Developmental and Comparative Immunology·Youliang RaoQingmei Li
Jun 4, 2014·Developmental and Comparative Immunology·Erick García-GarcíaVictoriano Mulero
Jun 5, 2007·Immunobiology·Erietta StelekatiSilvia Bulfone-Paus
Aug 26, 2006·Immunology and Allergy Clinics of North America·Mariana Castells
Sep 10, 2011·IUBMB Life·Martin Avila, Claudia Gonzalez-Espinosa
Jun 19, 2007·Journal of Leukocyte Biology·Srie Prihianti GondokaryonoHideoki Ogawa
Mar 30, 2020·Journal of Neuroinflammation·Marian Jesabel Pérez-RodríguezClaudia González-Espinosa
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Haiyan ChenAndrei E Medvedev
Feb 13, 2018·Immunological Reviews·Frank A RedegeldUlrich Blank
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alejandro Martín-ÁvilaClaudia González-Espinosa

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