MDI 301, a nonirritating retinoid, improves abrasion wound healing in damaged/atrophic skin.

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Roscoe L WarnerJ Varani

Abstract

MDI 301 is a picolinic acid-substituted ester of 9-cis retinoic acid. It has been shown in the past that MDI 301 increases epidermal thickness, decreases matrix metalloproteinase (MMP) activity, and increases procollagen synthesis in organ-cultured human skin. Unlike all-trans retinoic acid (RA), MDI 301 does not induce expression of proinflammatory cytokines or induce expression of leukocyte adhesion molecules in human skin. In the present study we examined topical MDI 301 treatment for ability to improve the structure and function of skin in three models of skin damage in rodents and for ability to improve abrasion wound healing in these models. MDI 301 was applied daily to the skin of rats treated with the potent corticosteroid, clobetasol propionate, to the skin of diabetic rats (8 weeks posttreatment with streptozotocin) and to the skin of aged (14-16-month-old) rats. In all three models, subsequently induced abrasion wounds healed more rapidly in the retinoid-treated animals than in vehicle-treated controls. Immediately after complete wound closure, tissue from the wound site (as well as from a control site) was put into organ culture and maintained for 3 days. At the end of the incubation period, culture fluids were asse...Continue Reading

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Citations

Dec 25, 2009·The Journal of Investigative Dermatology·Noriko Takahashi, Yasunori Fujiu
Sep 2, 2015·International Journal of Pharmaceutics·Dong Wuk KimHan-Gon Choi
Aug 8, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Narasimharao BhagavathulaJames Varani
Nov 20, 2009·The British Journal of Dermatology·N Takahashi, Y Fujiu
May 12, 2015·Drug Development Research·Sung Giu JinHan-Gon Choi
Dec 23, 2014·Cell Biochemistry and Function·Sandra RiegerThomas S Lisse
May 31, 2015·International Journal of Pharmaceutics·Sung Giu JinHan-Gon Choi
Jun 23, 2015·Genes & Diseases·Jillian CathcartJian Cao
Apr 8, 2017·Chemical Biology & Drug Design·Zoheyr MohammadiAli Mohammad Latifi
Jun 1, 2020·Anais Brasileiros De Dermatologia·Marcel Nani LeiteMarco Andrey Cipriani Frade
Aug 5, 2021·Heliyon·Marcel Nani Leite, Marco Andrey Cipriani Frade

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