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Mdivi-1 Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats, Possibly via Inhibition of Drp1-Activated Mitochondrial Fission and Oxidative Stress

Neurochemical Research

Feb 18, 2017

Pei WuHuaizhang Shi

Abstract

Mdivi-1 is a selective inhibitor of mitochondrial fission protein, Drp1, and can penetrate the blood-brain barrier. Previous studies have shown that Mdivi-1 improves neurological outcomes after ischemia, seizures and trauma but it remains unclear whether Mdivi-1 can attenuate early brai...read more

Mentioned in this Paper

CRMP1 gene
DENR gene
DNM1L gene
UTRN gene
Dnm1l protein, rat
Cleaved
Metabolic Inhibition
Brain Edema
Ischemia
Mitochondrial Fission
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Mdivi-1 Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats, Possibly via Inhibition of Drp1-Activated Mitochondrial Fission and Oxidative Stress

Neurochemical Research

Feb 18, 2017

Pei WuHuaizhang Shi

PMID: 28210956

DOI: 10.1007/s11064-017-2201-4

Abstract

Mdivi-1 is a selective inhibitor of mitochondrial fission protein, Drp1, and can penetrate the blood-brain barrier. Previous studies have shown that Mdivi-1 improves neurological outcomes after ischemia, seizures and trauma but it remains unclear whether Mdivi-1 can attenuate early brai...read more

Mentioned in this Paper

CRMP1 gene
DENR gene
DNM1L gene
UTRN gene
Dnm1l protein, rat
Cleaved
Metabolic Inhibition
Brain Edema
Ischemia
Mitochondrial Fission

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