MDM2 and p21WAF1/CIP1, wild-type p53-induced proteins, are regularly expressed by Sternberg-Reed cells in Hodgkin's disease

The Journal of Pathology
M Sánchez-BeatoP Martínez

Abstract

Mutations in the p53 tumour suppressor gene are the most common genetic alteration found in human cancers. Most of them are accompanied by stabilization of the protein, which renders it detectable through immunohistochemical techniques. Although p53 expression is a very common finding in Hodgkin's disease (HD), the status of the p53 gene is scarcely known, due to the difficulty in sequencing this gene in a lesion in which tumour cells are thought to constitute a very minor subpopulation, diluted in a background of supposedly benign cells. The pattern of expression of two downstream p53 proteins (MDM2 and p21 WAF1/CIP1, was studied as an indirect way of assessing p53 gene status. MDM2 is a wild-p53 inducible protein which may form a complex with p53, abrogating its function, as has been found in human sarcomas and other malignancies. p21WAF1/CIP1 is another protein inducible by wild-type p53, involved in inhibiting cell-cycle progression, through binding to cyclin/cyclin-dependent-kinase complexes. MDM2 and p21WAF1/CIP1 immunostaining was detected in all the cases analysed, independently of histological type, and were mainly present in Sternberg-Reed and Hodgkin (H & SR) cells. These immunohistochemical results were confirmed by...Continue Reading

References

Mar 1, 1992·The Journal of Pathology·R VilluendasP Martinez
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 6, 1991·Nature·A J LevineC A Finlay
Oct 5, 1995·The New England Journal of Medicine·M HummelH Stein
Feb 1, 1995·The Journal of Pathology·L XerriJ Hassoun
Sep 7, 1994·Journal of the National Cancer Institute·V A FlørenesO Fodstad
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Y ChenM B Kastan
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Feb 1, 1994·Molecular and Cellular Biology·D S HainesD L George
Feb 1, 1994·British Journal of Cancer·M A PirisF ] Pezella F [corrected to Pezzella
Jun 1, 1993·American Journal of Clinical Pathology·I A DoussisD Y Mason
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R K GuptaJ G Bodmer

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Citations

Jun 14, 2014·Leukemia & Lymphoma·Eleni C GeorgiadiIpatia A Doussis-Anagnostopoulou
Jul 13, 2007·São Paulo Medical Journal = Revista Paulista De Medicina·Gevina Silva PinheiroJosé Salvador Rodrigues de Oliveira
Apr 11, 2003·Leukemia & Lymphoma·Amalia LevyDaniel Benharroch
Sep 9, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Maria BaiPanagiotis Kanavaros
Aug 27, 2003·Genes, Chromosomes & Cancer·Daniel T Y ChuiRuth F Jarrett
Aug 10, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A F LauritzenE Ralfkiaer
Jul 1, 1997·The Journal of Pathology·J LorenzenR Fischer
Oct 24, 2002·Blood·Margarita Sánchez-BeatoMiguel A Piris
Mar 21, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Donna A WhyteEdward J Shillitoe
Mar 29, 2001·Hematological Oncology·W C Chan
Sep 11, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jinfen Wang, Clive R Taylor
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elias DrakosGeorge Z Rassidakis

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