Abstract
Mutations in the p53 tumour suppressor gene are the most common genetic alteration found in human cancers. Most of them are accompanied by stabilization of the protein, which renders it detectable through immunohistochemical techniques. Although p53 expression is a very common finding in Hodgkin's disease (HD), the status of the p53 gene is scarcely known, due to the difficulty in sequencing this gene in a lesion in which tumour cells are thought to constitute a very minor subpopulation, diluted in a background of supposedly benign cells. The pattern of expression of two downstream p53 proteins (MDM2 and p21 WAF1/CIP1, was studied as an indirect way of assessing p53 gene status. MDM2 is a wild-p53 inducible protein which may form a complex with p53, abrogating its function, as has been found in human sarcomas and other malignancies. p21WAF1/CIP1 is another protein inducible by wild-type p53, involved in inhibiting cell-cycle progression, through binding to cyclin/cyclin-dependent-kinase complexes. MDM2 and p21WAF1/CIP1 immunostaining was detected in all the cases analysed, independently of histological type, and were mainly present in Sternberg-Reed and Hodgkin (H & SR) cells. These immunohistochemical results were confirmed by...Continue Reading
References
Mar 1, 1992·The Journal of Pathology·R VilluendasP Martinez
Jun 26, 1992·Cell·J MomandA J Levine
Jul 2, 1992·Nature·J D OlinerB Vogelstein
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 6, 1991·Nature·A J LevineC A Finlay
Apr 11, 1985·Nucleic Acids Research·J Y TsoR Wu
Sep 1, 1995·The Journal of Pathology·J C MartinezP Martínez
Oct 5, 1995·The New England Journal of Medicine·M HummelH Stein
Feb 1, 1995·The Journal of Pathology·L XerriJ Hassoun
Apr 15, 1995·Genes & Development·K F MacleodT Jacks
Jun 16, 1994·Nature·S WagaB Stillman
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·R KüppersM L Hansmann
Sep 7, 1994·Journal of the National Cancer Institute·V A FlørenesO Fodstad
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Y ChenM B Kastan
Jun 15, 1994·International Journal of Cancer. Journal International Du Cancer·J RothM Pfreundschuh
Nov 19, 1993·Cell·J W HarperS J Elledge
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Feb 1, 1994·Molecular and Cellular Biology·D S HainesD L George
Feb 1, 1994·British Journal of Cancer·M A PirisF ] Pezella F [corrected to Pezzella
Oct 1, 1993·Histopathology·P H McKeeP A Hall
Jun 1, 1993·American Journal of Clinical Pathology·I A DoussisD Y Mason
Feb 1, 1993·The Journal of Pathology·G NiedobitekE L Jones
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R K GuptaJ G Bodmer
Apr 29, 1993·Nature·J D OlinerB Vogelstein
Apr 1, 1993·The Journal of Pathology·J C MartínezP Martínez
Citations
Jun 14, 2014·Leukemia & Lymphoma·Eleni C GeorgiadiIpatia A Doussis-Anagnostopoulou
Aug 29, 2012·Clinical & Developmental Immunology·Luis de la Cruz-MerinoTomás Álvaro
Jul 13, 2007·São Paulo Medical Journal = Revista Paulista De Medicina·Gevina Silva PinheiroJosé Salvador Rodrigues de Oliveira
Mar 23, 2000·The Journal of Pathology·Z KolarP G Murray
Apr 11, 2003·Leukemia & Lymphoma·Amalia LevyDaniel Benharroch
Sep 9, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Maria BaiPanagiotis Kanavaros
Aug 27, 2003·Genes, Chromosomes & Cancer·Daniel T Y ChuiRuth F Jarrett
Aug 10, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A F LauritzenE Ralfkiaer
Jul 1, 1997·The Journal of Pathology·J LorenzenR Fischer
Jun 19, 2002·Blood·Danny F DukersJoost J Oudejans
Mar 22, 2001·British Journal of Haematology·M KüpperL Trümper
Oct 24, 2002·Blood·Margarita Sánchez-BeatoMiguel A Piris
Mar 21, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Donna A WhyteEdward J Shillitoe
Mar 29, 2001·Hematological Oncology·W C Chan
Sep 11, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jinfen Wang, Clive R Taylor
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elias DrakosGeorge Z Rassidakis