PMID: 7519048Apr 1, 1994Paper

MDM2 gene amplification correlates with ring chromosome in soft tissue tumors

Genes, Chromosomes & Cancer
M NilbertN Mandahl

Abstract

The human homolog of the murine double minute type 2 gene (MDM2) has been cloned and mapped to 12q13-14. The gene presumably functions as a cellular regulator and mediator of TP53 function. Amplification of the MDM2 gene has recently been observed in soft tissue sarcoma and in osteosarcoma. We studied MDM2 amplification in a series of 94 mesenchymal tumors and found 3-20-fold amplification in 20 tumors: in 10 of 49 malignant fibrous histiocytomas (MFH), in 1 of 2 pleomorphic liposarcomas, in 6 of 7 atypical lipomas, and in 3 of 12 typical lipomas. Normal hybridization patterns were detected in all 16 myxoid liposarcomas, in all 3 leiomyosarcomas, and in all 5 leiomyomas studied. The MDM2 amplification correlated with the presence of marker ring chromosomes; of the 10 MFH with MDM2 amplification, 5 had ring chromosomes, compared to 4 of 39 without MDM2 amplification, and all 9 liposomas with MDM2 amplification had ring chromosomes, in 5 of the tumors as the sole karyotypic anomaly. The correlation between ring chromosomes and MDM2 gene amplification indicates that the marker rings of MFH and of atypical lipoma often harbor genetic material derived from chromosome 12.

References

May 10, 1991·International Journal of Cancer. Journal International Du Cancer·C Sreekantaiah, A A Sandberg
Jan 1, 1991·Genes, Chromosomes & Cancer·B JohanssonF Mitelman
May 1, 1990·Genes, Chromosomes & Cancer·M Nibert, S Heim
Sep 1, 1989·Genes, Chromosomes & Cancer·N MandahlF Mitelman
Dec 1, 1988·Cancer·W B LaskinF M Enzinger
Jan 1, 1988·Cytogenetics and Cell Genetics·K ArhedenF Mitelman
Aug 1, 1988·Plastic and Reconstructive Surgery·W C Jennings, B Say
Apr 1, 1993·Cancer Genetics and Cytogenetics·F PedeutourC Turc-Carel

❮ Previous
Next ❯

Citations

Jun 1, 1996·Genes, Chromosomes & Cancer·P F ChoongA Rydholm
Aug 10, 1999·Genes, Chromosomes & Cancer·W V YotovE Levy
Aug 26, 2000·Genes, Chromosomes & Cancer·N SirventF Pedeutour
Dec 24, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Erich Gebhart
Jul 1, 1996·Cancer Genetics and Cytogenetics·N MandahlF Mitelman
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R CorviM Schwab
Apr 25, 2003·Experimental and Molecular Pathology·Alexander J R Bishop, Robert H Schiestl
Dec 6, 2001·Cancer Genetics and Cytogenetics·A ForusF Pedeutour
Apr 12, 2002·Cancer Genetics and Cytogenetics·Cyril FoaFlorence Pedeutour
Aug 1, 1995·Cancer Genetics and Cytogenetics·M NilbertN Mandahl
Jan 15, 1998·Cancer Genetics and Cytogenetics·H SchmidtF W Rath
Dec 9, 1998·Cancer Genetics and Cytogenetics·D GisselssonN Mandahl
Mar 24, 1999·Cancer Genetics and Cytogenetics·A Geurts van KesselR P Veth
Jul 22, 1998·Nucleic Acids Research·J MomandJ Niland
Jun 1, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Muna SabahElaine Kay
May 1, 2010·The American Journal of Surgical Pathology·Jennifer M BolandAndrew L Folpe
May 29, 2004·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Hirofumi NakanishiHideki Yoshikawa
Jan 24, 2012·European Journal of Gastroenterology & Hepatology·Ines ChaarSaadia Bouraoui
Apr 9, 2005·Cancer Investigation·Keith M SkubitzAmy P N Skubitz
Feb 1, 1995·The Journal of Pathology·M LadanyiJ H Healey
Oct 20, 1995·International Journal of Cancer. Journal International Du Cancer·T NakayamaM S Sasaki
May 20, 1998·Pathology, Research and Practice·K RadigA Roessner
Nov 3, 2007·Mayo Clinic Proceedings·Keith M Skubitz, David R D'Adamo
Mar 21, 2007·International Journal of Cancer. Journal International Du Cancer·Antoine ItalianoFlorence Pedeutour
Sep 21, 2011·Diagnostic Cytopathology·Leslie G Dodd
Mar 12, 2011·Pediatric Blood & Cancer·Winston W HuhSheri L Spunt
Nov 6, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
Apr 7, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
Aug 30, 2006·Cancer Genetics and Cytogenetics·Haroula TsarouhaNikos Pandis
Aug 26, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S H KimH S Ryu
Dec 18, 2014·Cancer Cell·Joshua J Waterfall, Paul S Meltzer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
C KuhnenK-M Müller
© 2021 Meta ULC. All rights reserved