MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians.

BMC Cancer
Joerg BittenbringKlaus Roemer

Abstract

SNP309 T/G (rs2279744) causes higher levels of MDM2, the most important negative regulator of the p53 tumor suppressor. SNP72 G/C (rs1042522) gives rise to a p53 protein with a greatly reduced capacity to induce apoptosis. Both polymorphisms have been implicated in cancer. The SNP309 G-allele has recently been reported to accelerate diffuse large B-cell lymphoma (DLBCL) formation in pre-menopausal women and suggested to constitute a genetic basis for estrogen affecting human tumorigenesis. Here we asked whether SNP309 and SNP72 are associated with DLBCL in women and are correlated with age of onset, diagnosis, or patient's survival. SNP309 and SNP72 were PCR-genotyped in a case-control study that included 512 controls and 311 patients diagnosed with aggressive NHL. Of these, 205 were diagnosed with DLBCL. The age of onset was similar in men and women. The control and patients group showed similar SNP309 and SNP72 genotype frequencies. Importantly and in contrast to the previous findings, similar genotype frequencies were observed in female patients diagnosed by 51 years of age and those diagnosed later. Specifically, 3/20 female DLBCL patients diagnosed by 51 years of age were homozygous for SNP309 G and 2/20 DLBCL females in t...Continue Reading

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May 11, 2010·Cold Spring Harbor Perspectives in Biology·Lukasz F GrocholaGareth L Bond
Dec 20, 2011·Pediatric Blood & Cancer·Adriana Helena de Oliveira ReisFernando Regla Vargas
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Jun 4, 2014·European Journal of Haematology·Gustav HedströmMattias Berglund
Jun 28, 2021·Pharmacology & Therapeutics·Daniele LavacchiStefania Nobili

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Datasets Mentioned

BETA
AF527840

Methods Mentioned

BETA
PCR

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