MDM2 overexpression is associated with short survival in adults with medulloblastoma

Neuro-oncology
M T GiordanaAdriano Chió

Abstract

In adult medulloblastoma, postoperative radiotherapy is significantly effective in prolonging time to recurrence and survival time; however, the response of individual cases to radiotherapy, that is the total survival, is different. Apoptosis is an important cellular response to radiation. It can be hypothesized that the individual radiosensitivity of medulloblastomas depends on the individual capability to undergo apoptosis. p53 protein is involved in the apoptotic response to ionizing radiation; loss of function of p53 can be the consequence not only of TP53 mutations, but also of amplification and/or overexpression of the MDM2 gene. We have analyzed cerebellar medulloblastomas from 51 adults (>16 years of age) for MDM2 gene amplification (by differential polymerase chain reaction assay), TP53 gene mutation (by polymerase chain reaction single-strand conformation polymorphism analysis of exons 5-8), and immunohistochemical expression of p53 (clone DO1) and MDM2 (clone IF2). The results have been evaluated in relation to age, tumor location, classic or desmoplastic type, MIB-1 labeling index, and total survival. No tumor had MDM2 amplification. Ten tumors had MDM2 positive tumor cells. One case had a mutated TP53 gene; 16/51 c...Continue Reading

References

Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P M ZeltzerR J Packer

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Citations

Oct 13, 2007·Journal of Neuro-oncology·Robert C CastellinoJohn Y H Kim
Apr 22, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hsi-Feng TuKuo-Wei Chang
May 15, 2007·International Journal of Radiation Oncology, Biology, Physics·Laetitia PadovaniChristian Carrie
Jul 23, 2015·Arquivos de neuro-psiquiatria·Richard Murdoch MontgomeryFabio Rogerio
Aug 15, 2002·Neuropathology and Applied Neurobiology·D Ellison
May 4, 2007·The EMBO Journal·Pierre-Olivier FrappartPeter J McKinnon
Jun 13, 2008·Acta neurochirurgica·F ZustovichG Cartei
May 1, 2012·Cell Cycle·Anastasia R GoloudinaOleg N Demidov
Feb 5, 2008·Journal of Neurosurgery·Anand V GermanwalaL Dade Lunsford
Mar 2, 2012·Neuro-oncology·Meghan C BussRobert C Castellino
Nov 16, 2013·Oncotarget·Anton HenssenJohannes H Schulte
Aug 20, 2016·Neuro-oncology·Benjamin H KannKenneth B Roberts
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pierre-Olivier FrappartPeter J McKinnon
Jan 1, 2003·The American Journal of Pathology·Charles G Eberhart
Oct 13, 2021·Molecular Cancer Research : MCR·Aisha NaeemChris Albanese

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis