MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit

Ophthalmic Plastic and Reconstructive Surgery
Frederick A JakobiecAaron Fay

Abstract

To distinguish, in a 36-year-old man, an atypical lipomatous neoplasm/well-differentiated liposarcoma from a spindle cell lipoma in a recurrent orbital tumor. Clinical, radiographic, and histopathologic evaluations coupled with immunohistochemical studies for CD34, factor XIII, bcl-2, S-100, muscle-specific actin, Ki-67, and MDM2. MDM2 gene amplification was discovered in the CD34 tumor cells. An average Ki-67 proliferation index of 28% was ascertained for the original and recurrent lesions. These findings established the diagnosis of a well-differentiated liposarcoma with lipoma-like and spindle cell features and ruled out a spindle cell lipoma. Well-differentiated liposarcoma is a slow growing, infiltrative, and nonmetastasizing neoplasm that is microscopically and diagnostically challenging. It can be reliably separated from a benign spindle cell or an atypical lipoma by using the markers MDM2 and Ki-67.

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Citations

Mar 5, 2014·Histopathology·Rebecca C StacyGunnlauger Petur Nielsen
Jan 18, 2015·Survey of Ophthalmology·Frederick A JakobiecSuzanne K Freitag
May 30, 2016·Archivos de la Sociedad Española de Oftalmología·A M Borbolla-PertierraP Velasco-Ramos
May 29, 2015·Ophthalmic Plastic and Reconstructive Surgery·Norman C Charles, Irina Belinsky
Mar 26, 2019·Ophthalmic Plastic and Reconstructive Surgery·Kyle McKeyTatyana Milman
May 31, 2019·Seminars in Ophthalmology·Paula Cortes BarrantesThaddeus P Dryja
Feb 7, 2018·Journal of Ophthalmic & Vision Research·Douglas P DworakDaniel Falco
May 14, 2014·Ophthalmic Plastic and Reconstructive Surgery·Devjyoti Tripathy, Ruchi Mittal
May 15, 2018·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·F Roberts, E M MacDuff
May 27, 2020·International Journal of Surgical Pathology·T C LamWah Cheuk
Dec 9, 2014·Proceedings·Ivan VrcekGrant Gilliland
Sep 30, 2020·Ophthalmic Plastic and Reconstructive Surgery·Julia Y KangHans E Grossniklaus

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