MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion

European Journal of Pharmacology
N AguirreJ Del Río

Abstract

One week after a single administration of 3,4-methylenedioxymethamphetamine (MDMA HCI, 30 mg/kg i.p.), 5-HT1A receptor density was significantly increased by approximately 25-30% in the frontal cortex and hypothalamus of rats. The increased density correlated with the potentiation of the hypothermic response to the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 1 mg/kg s.c.). Hypothalamic 5-HT7 receptors, which also bind 8-OH-DPAT, were not changed, however, by MDMA. Fluoxetine (5 mg/kg s.c.), ketanserin (5 mg/kg s.c.) or haloperidol (2 mg/kg i.p.), given 15 min prior to MDMA, prevented the depletion of 5-hydroxytryptamine (5-HT) induced by MDMA and also blocked the effects of this neurotoxin on 5-HT1A receptor density and on 8-OH-DPAT-induced hypothermia. The protection afforded by drugs against 5-HT loss did not correlate, however, with the antagonism of the acute hyperthermic effect of MDMA. The present results indicate that drugs able to prevent or to attenuate MDMA-induced 5-HT loss also prevent the changes in 5-HT1A receptor density as well as the enhanced hypothermic response to the 5-HT1A receptor agonist 8-OH-DPAT in MDMA-treated rats.

References

Jul 1, 1992·British Journal of Pharmacology·M T O'ConnellG Curzon
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·D N Middlemiss, M D Tricklebank
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·C J GordonD B Miller
Jan 1, 1990·Journal of Neurochemistry·D J McKenna, S J Peroutka
Feb 13, 1990·European Journal of Pharmacology·T SharpD G Grahame-Smith
May 31, 1990·European Journal of Pharmacology·C J SchmidtV L Taylor
Jan 1, 1985·Journal of Neural Transmission·S Hjorth
May 20, 1983·European Journal of Pharmacology·D N Middlemiss, J R Fozard
May 1, 1995·British Journal of Pharmacology·Z P ToL B Jakeman
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·M G McNamaraB E Leonard
Jan 4, 1996·European Journal of Pharmacology·A C SantucciV Haroutunian
Oct 25, 1996·Biochemical Pharmacology·J E SpragueD E Nichols

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Citations

Apr 18, 2009·Molecular Neurobiology·João Paulo CapelaFélix Carvalho
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·R A Glennon, R Young
Feb 15, 2000·Pharmacology, Biochemistry, and Behavior·M BarrionuevoB Lasheras
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brian J PiperJerrold S Meyer
Feb 28, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Murray R ThompsonIain S McGregor
Oct 20, 2006·Neurotoxicology and Teratology·Maria AbergSari Izenwasser
Dec 4, 2012·Neuropharmacology·A J D NelsonH J Cassaday
Dec 9, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Armanda Teixeira-GomesJoão Paulo Capela
Dec 1, 2009·Biochemical and Biophysical Research Communications·Kazuhiro TanakaAkemichi Baba
Jun 8, 2000·Bioorganic & Medicinal Chemistry Letters·M L López-RodríguezJ L Lavandera
Oct 27, 2004·Bioorganic & Medicinal Chemistry Letters·Andrzej J BojarskiTeresa Kowalska
Mar 3, 2006·Journal of Psychopharmacology·Neil Easton, Charles A Marsden
Feb 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Boris B QuednowMichael Wagner
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Iain S McGregorAndrew J Lawrence
Dec 6, 2017·Frontiers in Psychiatry·Kristýna ŠtefkováTomáš Páleníček
Jun 30, 2019·Pharmacological Reviews·Madeline M Pantoni, Stephan G Anagnostaras
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
May 9, 2000·Journal of Neurochemistry·A García-OstaJ Del Río
Dec 18, 2020·Pharmacological Reviews·Antonio InserraGabriella Gobbi
Nov 12, 2017·Pharmacology, Biochemistry, and Behavior·A Newman-TancrediM A Varney
Feb 24, 2007·Progress in Neurobiology·Christian P MüllerMaria A De Souza Silva
Oct 28, 2011·Journal of Medicinal Chemistry·Isabel MarcoMaría L López-Rodríguez

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