MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats

Alcohol
S M MeehanM D Schechter

Abstract

Selectively bred high- and low-alcohol-drinking (HAD/LAD) rats were trained to discriminate the interoceptive stimuli produced by IP-administered 600 mg/kg ethanol (10% w/v in a two-lever, food-motivated operant task. Once criterion discrimination was attained, animals were tested with 3.0, 1.5, 1.0, and 0.5 mg/kg MDMA. Although no differences in alcohol discrimination were observed between the HAD and LAD animals, the HAD line was significantly more sensitive than the LAD line to the effects of MDMA. These results provide additional information to the growing body of evidence suggesting serotonergic mediation of some of the behavioral effects of ethanol.

References

Sep 1, 1992·Pharmacology, Biochemistry, and Behavior·A H RezvaniC J Gordon
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·A H Rezvani, D S Janowsky
Dec 1, 1988·Pharmacology, Biochemistry, and Behavior·M D Schechter
May 1, 1988·Pharmacology, Biochemistry, and Behavior·S A Signs, M D Schechter
Jan 1, 1988·Journal of Neural Transmission·D T WongT K Li
Jun 10, 1981·European Journal of Pharmacology·A Dumbrille-Ross, S W Tang
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·W J McBrideT K Li
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·T L GordonM D Schechter

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Citations

Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·T L GordonM D Schechter
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Richard A GlennonJagadeesh B Rangisetty
Jun 18, 2002·Alcoholism, Clinical and Experimental Research·Keith L Shelton, Kathleen A Grant

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