MDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress

Journal of Psychopharmacology
Andy C Parrott

Abstract

Many recreational ecstasy/MDMA users display neuropsychobiological deficits, whereas others remain problem free. This review will investigate some of the drug and non-drug factors which influence the occurrence of these deficits. Acute and chronic MDMA usage are both important. Intensive use within a session is often associated with more problems. In term of lifetime usage, novice users generally remain unimpaired, whereas most heavy users report memory or other psychobiological problems which they attribute to ecstasy. These complaints are confirmed by objective deficits in working memory, attention, frontal-executive, and episodic memory tasks. Psychobiological deficits include disturbed sleep, sexual dysfunction, reduced immuno-competence, and increased oxidative stress. Further MDMA-related factors which may contribute to these changes, include acute and chronic tolerance, and drug dependence. Around 90ñ95% of ecstasy/MDMA users also take cannabis, and this can independently contribute to the adverse neuropsychobiological pro.les; although in some situations the acute co-use of these two drugs may be interactive rather than additive, since cannabis has relaxant and hypothermic properties. Alcohol, nicotine, amphetamine, and...Continue Reading

References

Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·C J GordonD B Miller
Nov 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·F J CreightonC E Hyde
Oct 1, 1991·Journal of Clinical Psychopharmacology·U D McCann, G A Ricaurte
Oct 1, 1986·Journal of Psychoactive Drugs·J Downing
Oct 1, 1986·Journal of Psychoactive Drugs·C L Renfroe
Nov 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·R S Cohen
Oct 5, 1996·Lancet·E WebbF Kamali
Mar 14, 1997·Drug and Alcohol Dependence·S WilliamsonJ Strang
May 19, 1998·Journal of Psychopharmacology·A C ParrottK Wesnes
Aug 27, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F X VollenweiderT Huber
Sep 19, 1998·European Addiction Research·P SchusterH U Wittchen
Oct 27, 1998·Drug and Alcohol Dependence·F SchifanoR Bricolo
Dec 8, 1998·Lancet·W Hall, N Solowij
Dec 17, 1998·Neurology·K I BollaG A Ricaurte
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·K M HegadorenM Bourin
Mar 18, 1999·Drug and Alcohol Dependence·K L Jansen
Jul 13, 1999·Drug and Alcohol Dependence·L ToppN Solowij
Jan 6, 2000·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·K SuyL Baute
Mar 18, 2000·Toxicology Letters·P McGuire
May 2, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F TuchtenhagenE Gouzoulis-Mayfrank
May 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·E Gouzoulis-MayfrankH Sass
May 24, 2000·Drug and Alcohol Dependence·A C ParrottJ J Turner
Jun 1, 2000·British Journal of Psychology·M WareingP N Murphy
Jul 13, 2000·Addiction·W Pedersen, A Skrondal
Aug 25, 2000·Psychopharmacology·J Rodgers
Nov 1, 2000·JAMA : the Journal of the American Medical Association·M BaggottJ Zehnder
Nov 18, 2000·The American Psychologist·A C Parrott

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Citations

Mar 7, 2012·Archives of Toxicology·Márcia CarvalhoMaria de Lourdes Bastos
Jul 9, 2009·Psychopharmacology·Robin L Carhart-HarrisSue J Wilson
Apr 24, 2013·Psychopharmacology·Claire WhiteMark Edwards
Apr 17, 2010·Journal of Clinical and Experimental Neuropsychology·Karen L Hanson, Monica Luciana
Jul 16, 2008·Journal of Clinical Psychopharmacology·Erin A KolbrichMarilyn A Huestis
Aug 22, 2012·Pediatrics·Lynn T SingerAndrew C Parrott
Dec 3, 2013·Acta Neuropathologica·Jean Lud CadetChristopher Mark Milroy
Oct 14, 2009·Psychopharmacology·Thelma SchiltBen Schmand
Dec 17, 2009·Substance Use & Misuse·Stella Pereira de AlmeidaMaria Teresa Araujo Silva
Mar 29, 2008·Molecular and Cellular Endocrinology·L FattoreW Fratta
Oct 13, 2015·Progress in Neurobiology·Rosario MoratallaMicaela Morelli
Mar 6, 2012·Human Psychopharmacology·Elizabeth MurrayJohn Brown
Jul 16, 2011·Pharmacology, Biochemistry, and Behavior·Wael M Y MohamedByron C Jones
Oct 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Andrew C Parrott, Lucy Young
Jul 23, 2013·Pharmacology, Biochemistry, and Behavior·J H BroadbearP Mak
May 17, 2014·Journal of Psychoactive Drugs·Andrew C Parrott
Sep 9, 2008·Neuroscience and Biobehavioral Reviews·Richard Hammersley, Marie Reid
Mar 20, 2010·Journal of Psychoactive Drugs·Katy A JonesA C Parrott
Dec 21, 2012·Journal of Psychopharmacology·Ac ParrottJ Thome

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