MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Felix MüllerStefan Borgwardt

Abstract

It has been reported that serotonergic hallucinogens like lysergic acid diethylamide (LSD) induce decreases in functional connectivity within various resting-state networks. These alterations were seen as reflecting specific neuronal effects of hallucinogens and it was speculated that these shifts in connectivity underlie the characteristic subjective drug effects. In this study, we test the hypothesis that these alterations are not specific for hallucinogens but that they can be induced by monoaminergic stimulation using the non-hallucinogenic serotonin-norepinephrine-dopamine releasing agent 3,4-methylenedioxymethamphetamine (MDMA). In a randomized, placebo-controlled, double-blind, crossover design, 45 healthy participants underwent functional magnetic resonance imaging (fMRI) following oral administration of 125 mg MDMA. The networks under question were identified using independent component analysis (ICA) and were tested with regard to within-network connectivity. Results revealed decreased connectivity within two visual networks, the default mode network (DMN), and the sensorimotor network. These findings were almost identical to the results previously reported for hallucinogenic drugs. Therefore, our results suggest that...Continue Reading

References

Apr 16, 1998·European Journal of Pharmacology·M TatsumiE Richelson
Jun 20, 1998·Neurology·W C Koller, M G Rueda
May 19, 2001·Mayo Clinic Proceedings·E Richelson
Oct 31, 2002·Human Psychopharmacology·Matthias E. Liechti, Franz X. Vollenweider
Sep 14, 2004·Primary Care Companion to the Journal of Clinical Psychiatry·Stephen M. StahlSusan Learned-Coughlin
May 2, 2006·Journal of Magnetic Resonance Imaging : JMRI·Richard G Wise, Irene Tracey
Jun 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clare KellyKatie McMahon
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithChristian F Beckmann
Sep 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Jonathan PriceGuy M Goodwin
Jan 12, 2010·Human Brain Mapping·Ahmed Abou-ElseoudVesa Kiviniemi
Apr 13, 2010·Journal of Neuroscience Methods·Robert E KellyMatthew J Hoptman
Dec 17, 2010·Human Brain Mapping·Erik Barry ErhardtVince D Calhoun
Mar 29, 2011·Frontiers in Systems Neuroscience·Elena A AllenVince D Calhoun
Jun 16, 2011·Psychopharmacology·Roland R GriffithsRobert Jesse
Aug 4, 2011·NeuroImage·Koene R A Van DijkRandy L Buckner
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Boris B QuednowFranz X Vollenweider
Oct 5, 2011·Cerebral Cortex·Xi-Nian ZuoMichael P Milham
May 31, 2012·Brain Connectivity·Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon
Aug 18, 2012·British Journal of Pharmacology·L D SimmlerM E Liechti
Dec 25, 2012·Journal of Neuroscience Methods·Jean Michel PignatThierry Pun
Feb 8, 2013·JAMA Psychiatry·Jonathan PosnerBradley S Peterson
Oct 10, 2013·The International Journal of Neuropsychopharmacology·Cédric M HysekMatthias E Liechti
May 28, 2014·Human Brain Mapping·Sophia MuellerThomas Meindl
Jul 24, 2014·Journal of Psychopharmacology·Yasmin SchmidMatthias E Liechti
Sep 23, 2014·Current Biology : CB·Alexander SchaeferJulia Sacher
Oct 14, 2014·Frontiers in Human Neuroscience·Benedikt SundermannBettina Pfleiderer
Jan 13, 2015·Biological Psychiatry·Yasmin SchmidMatthias E Liechti
Aug 19, 2015·NeuroImage·Bernadet L KlaassensJoop M A van Gerven
Feb 5, 2016·Pharmacological Reviews·David E Nichols
Apr 14, 2016·The Lancet. Psychiatry·Michael C MithoeferTimothy D Brewerton
Apr 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Robin L Carhart-HarrisDavid J Nutt
Apr 15, 2016·Neuroinformatics·Chao-Gan YanYu-Feng Zang
Apr 18, 2016·Current Biology : CB·Enzo TagliazucchiRobin Carhart-Harris
May 25, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Anna RickliMatthias E Liechti
Jun 2, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patrick C DolderMatthias E Liechti
Jun 14, 2016·Current Topics in Medicinal Chemistry·Peng LiKimberly E Vanover

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Citations

May 15, 2021·The International Journal of Neuropsychopharmacology·David B YadenFrederick S Barrett
Jul 12, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martin K MadsenPatrick M Fisher
Sep 20, 2021·The International Journal of Neuropsychopharmacology·Genís OnaJordi Riba

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Methods Mentioned

BETA
pregnancy test

Clinical Trials Mentioned

NCT01951508
NCT03019822

Software Mentioned

SPM
G1
CONN
GICA3
DPABI
MATLAB
CONN toolbox
SPM12
CompCor
FastICA

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