MDMA modifies active avoidance learning and recall in mice

Psychopharmacology
José Manuel TrigoPatricia Robledo

Abstract

Several studies have suggested the existence of cognitive deficits after repeated or high doses of 3,4-methylenedioxymethamphetamine (MDMA) in humans and experimental animals. However, the extent of the impairments observed in learning or memory tasks remains unclear. The objective of this study was to evaluate the effects of different dosing regimens of MDMA on the ability of mice to learn and recall an active avoidance task. Animals were treated with MDMA (0, 1, 3, 10 and 30 mg/kg) under four different experimental conditions, and active avoidance acquisition and recall were evaluated. In experiments 1 and 2, MDMA was administered 1 h before different active avoidance training sessions. In experiments 3 and 4, mice received a repeated treatment with MDMA before or after active avoidance training, respectively. Changes in presynaptic striatal dopamine transporter (DAT) binding sites were evaluated at two different time points in animals receiving a high dose of MDMA (30 mg/kg) or saline twice a day over 4 days. MDMA administered before the active avoidance sessions interfered with the acquisition and the execution of a previously learned task. A repeated treatment with high doses of MDMA administered before training reduced ac...Continue Reading

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Citations

Apr 18, 2009·Molecular Neurobiology·João Paulo CapelaFélix Carvalho
May 13, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H P van WelJ G Ramaekers
Jan 21, 2012·Addiction Biology·Xavier ViñalsPatricia Robledo
Mar 3, 2010·Annual Review of Clinical Psychology·Emma Barkus, Robin M Murray
Dec 23, 2009·Neuroscience Letters·Alejandra Arias-CavieresBernardo Morales
Jun 21, 2019·Journal of Psychopharmacology·Sonia AbadElena Escubedo
Aug 18, 2018·Frontiers in Behavioral Neuroscience·Barbara BudzynskaAnna Boguszewska-Czubara

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